An in vitro Platform of Antigen-Presenting Cells to Evaluate Critical Quality Attributes in Vaccine Formulations

Sanofi-Pasteur is developing new vaccine formulations that need to be evaluated on their efficacy and potency. Traditionally, the use of animal models to predict human immunity has been accepted as the best way to select vaccine formulations. However, animal models can be costly and time-prohibitive, and the assays employed to assess vaccine efficacy and potency […]

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Novel Treatments for bladder inflammation and pain

Interstitial cystitis is an inflammatory disease of the urinary bladder and is recognized as a serious medical condition associated with a profoundly negative impact on patients’ quality of life. Currently, there are no widely acknowledged causes of this disorder and no effective treatments available. Panag is a Halifax based drug company which focuses on development […]

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Exploration and Development of an Active Assisted Living Data Sharing Infrastructure Aimed at Supporting the Development of Standards, Guidelines, and Certification Programs – Blockchain for Consent Management

The Ubiquitous Health Technology Lab (UbiLab) will explore the development of a data integration framework and recommendation for associated standards that aims at combining data from (1) smart home systems, (2) AAL or IoT for health technology, (3) mHealth, and (4) wearables. Important areas of data management will be explored, as for example security and […]

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Medical cannabis and cancer: A qualitative exploration.

In recent years Medical Cannabis (MC) has become a much discussed and ever-evolving topic in Canada. A growing number of studies have highlighted the medical and multidimensional benefits of cannabis. The question of the spiritual benefits of MC forms part of this holistic approach. Qualitative research on medical cannabis is limited, and most of it […]

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The role of marginal B cells in atherosclerosis

Atherosclerosis is an inflammatory disease characterized by the accumulation of cholesterol, fat and immune cells deposits in large arteries. In the body, the main inflammatory modulators are called immune cells. We have recently discovered that a type of immune cell called marginal zone B (MZB) cells protect from atherosclerosis (Nus, Nat Med 2017). In response […]

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Serum Protein and Antibody Interactions with Immunomagnetic Cell Isolation Particles

Immunomagnetic cell isolation particles are widely used to separate cells from complex, biological environments, such as blood, urine, or bone marrow. Cell isolation particles are typically decorated with specialized antibodies to bind to targeted cell surfaces via specific antibody–antigen interactions. These interactions can be disturbed by the presence of serum proteins, which are common constituents […]

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Role of neuronal nitric oxide synthase in neurovascular coupling

My project aims to unravel how the brain can precisely deliver blood flow to match neuronal metabolism, termed neurovascular coupling (NVC). Evidence suggests that functional changes within the neurovascular unit, which is comprised of the neuron, the astrocyte and the vascular contractile cell, are associated with the development of vascular-cognitive impairment, as well as treatment […]

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Development of a comprehensive educational program forLaparoscopic Inguinal Hernia Repair and a randomized controlled trail for IncisionalHernia after abdomal surgery to Increase the safe and effectiv

Compared to “open” surgery, laparoscopic inguinal hernia repair done with 3 small incisions in the abdominal wall, is associated with less pain and quicker recovery. Many surgeons are not comfortable performing this operation since it can be challenging to learn. The purpose of this research program is 1) to describe the practice patterns of surgeons […]

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The Effect of Degenerative Spine Disease on Neuromuscular Pain and Function

Despite its growing prevalence of chronic musculoskeletal disease in society, its cause is still poorly understood. Emerging research suggests that degenerative spine disease may be an important facilitator to the development of chronic inflammatory musculoskeletal disease. We aim to investigate the effect of degenerative spine disease on muscle inflammation, pain and dysfunction by using an […]

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