In the last years imaging using miniature microscopes (mini-microscopes also called mini-endoscopes) has become a method of choice for the understanding of activity at the cellular and network levels in different brain regions, in freely behaving animals. However, mini-microscopes are connected with wires to other devices, which largely alleviate the use of these imaging systems […]

The overall goal of this project is to develop more cost-effective methods for generating monoclonal antibodies (mAb) against cancer biomarkers. While the traditional protocols for mAb generation used by MédiMabs have been established decades ago, recent technological developments have opened the door to new, and potentially far more efficient, methodologies. In this project, we will […]

The overall goal of this project is to develop more cost-effective methods for generating monoclonal antibodies (mAb) against cancer biomarkers. While the traditional protocols for mAb generation used by MédiMabs have been established decades ago, recent technological developments have opened the door to new, and potentially far more efficient, methodologies. In this project, we will […]

Over 6.5 million people in North America live with chronic wounds which pose a burden on their quality of life and the healthcare system. Chronic wounds are estimated to cost over $30 billion per year. Swift Medical is a pioneer in point-of-care imaging for wounds. Their mobile apps allow the reliable and accurate measurement of […]

Over 6.5 million people in North America live with chronic wounds which pose a burden on their quality of life and the healthcare system. Chronic wounds are estimated to cost over $30 billion per year. Swift Medical is a pioneer in point-of-care imaging for wounds. Their mobile apps allow the reliable and accurate measurement of […]

Plants including Cannabis host distinct beneficial microbial communities on and inside their tissues designated the plant microbiota from the moment that they are planted into the soil as seed. Understanding the microbial partnerships with Cannabis has the potential to affect agricultural practices by improving plant fitness and production yield of Cannabinoids. Much less is known […]

The objective of this research is to investigate long-term interaction between host cell and pathogen. Research will be proceed using ATPS(Aqueous two phase system) and hydrogel. ATPS enable pathogen to form localized biofilm on mammalian cell tissue. To see long-term interaction, biofilm will be stably localized on mammalian cell using hydrogel, which protect mammalian cell […]

Mycophenolic acid (MPA) and tacrolimus (TAC) are approved for use in post-transplant immunosuppressants to prevent graft rejection after solid organ transplantation. MPA and TAC are frequently used in combination as an immunosuppressive regimen in pediatric kidney transplant recipients. However, these two drugs have narrow therapeutic ranges and large interindividual pharmacokinetic and pharmacodynamic variabilities. What’s more, […]

Drug metabolism is a fundamental step of drugs to act and move in the body. Cytochorome P450 (CYP) enzymes, the most important metabolizing enzymes, are superfamily that metabolize a vast array of compounds, especially drugs. While drug metabolism occurs predominantly in the liver so that CYP enzymes in other organs has been understudied, brain CYP-mediated […]

Les granulocytes sont une première ligne de défense très efficace contre les infections. Lorsqu’ils sont en nombre insuffisant ou qu’ils se dérèglent, de graves infections peuvent survenir. La transfusion de granulocytes est alors toute indiquée pour les patients aux prises avec une infection sévère résistante aux traitements habituels. Toutefois, nous ne savons pas si ces […]

Therapeutic antibodies have been developed against a variety cancer cell surface proteins. These antibodies activate immune surveillance mechanisms that lead to destruction of cancer cells. Therapeutic antibody efficacy can be enhanced or might have unforeseen detrimental effects due to activation or inhibition of intracellular signaling pathways. Recent evidence suggests that the targeting of subtypes of […]

Therapeutic antibodies have been developed against a variety cancer cell surface proteins. These antibodies activate immune surveillance mechanisms that lead to destruction of cancer cells. Therapeutic antibody efficacy can be enhanced or might have unforeseen detrimental effects due to activation or inhibition of intracellular signaling pathways. Recent evidence suggests that the targeting of subtypes of […]