Molecular characterization, autogenous vaccine manufacturing and vaccine potency studies of two pathogenic Avian Reovirus (ARV) field isolates from the Province of Alberta – Part 2

Avian Reovirus (ARV) is an economically important virus that is affecting poultry flocks in Alberta. Birds infected with pathogenic ARV may develop a disease named viral arthritis/tenosynovitis which is characterised by lameness, swollen joints, rupture of tendons and increase mortality. The disease is controlled by parent stock vaccination with live and/or inactivated antigen to provide […]

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Non-invasive brain stimulation enhanced motor learning and resting state functional connectivity in typically developing children and children with perinatal stroke

How non-invasive brain stimulation works is poorly understood. Advanced neurotechnologies are providing new opportunities to explore transcranial direct current stimulation (tDCS) mechanisms. Ironically, the developing brain is more “plastic” and highly capable of change, yet tDCS mechanisms are almost exclusive to adults. Though treatment options are limited, we recently demonstrated for the first time that […]

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Local Growth Factor Presentation by Macrophages

Fibrosis comprises different connective tissue disorders that ultimately result in deposition of detrimental scar tissue in injured or inflamed organs. The culprit cells for organ scarring are called myofibroblasts because they secrete fibrous collagen matrix (“fibro”) that is contracted (“myo”) into scar tissue. Excessive myofibroblast activities are responsible for loss of function of vital organs […]

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Drug Repurposing for Neuromuscular Diseases

SMA is a neurodegenerative disease characterised by the loss of lower motor neurons and is an incurable disease. SMA is the leading genetic cause of early childhood lethality, with an incidence of 1 in 6,000 to 10,000 live births and a carrier frequency of 1 in 35-40. Current therapeutic strategies under development are almost exclusively […]

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A randomized control trial comparing weight loss effects between the Keyto virtual “ketogenic diet” program compared to a standard-care weight loss app

Over 60% of overweight or obese individuals attempt weight loss diets each year. Although many different dietary approaches can lead to weight loss, increasing evidence suggests that a very low-carbohydrate ketogenic diet may have superior metabolic and weight loss effects. However, any diet is only as effective as adherence to it and adherence requires effective […]

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Epigenetic effects of smolt-to-adult rearing in Atlantic Salmon

Stocking remains an important component of managing and conserving Atlantic Salmon populations, but it also has the potential to cause negative effects to wild populations. To understand the cause of these effects and the potential consequences of using a smolt-to-adult supplementation approach we will use cutting edge technology to investigate epigenetic changes in captive reared […]

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Spatial and temporal trends in nesting habitat use and availability for cavity nesting waterfowl in the lower Saint John River floodplain

Cavity-nesting ducks, including the wood duck, common goldeneye, and hooded merganser, are of interest in wildlife management programs due to their value to hunters and conservation groups. The lower Saint John River floodplain (New Brunswick, Canada) is a major breeding region for these species in Atlantic Canada that has experienced significant changes in recent decades. […]

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Quantification of Intra-Host Diversity of Piscine orthoreovirus (PRV-1) Infecting Atlantic and Chinook Salmon in BC

The decline in many populations of wild Pacific salmon is of great concern given their critical importance to First Nations, the ecosystems of the Pacific Northwest, and wild and farmed fisheries. The conservation efforts of the Pacific Salmon Foundation (PSF) have provided opportunity for research into infectious diseases like Heart and Skeletal Muscle Inflammation (HSMI) […]

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Selective Ablation of Circulating Tumor Cells by Dynamic Photothermal Therapy

Cancer metastasis is responsible for 90% of cancer deaths. In metastasis, a group of cancer cells detach from the tumor, entre the blood stream and ultimately make new colonies in other organs. In this study we aim to develop a new technology to target these cancerous cells in the blood circulation with laser irradiation. We […]

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Measuring the contributions of non-crop areas to precision canola yield

Canola growers recognize that the beneficial arthropods that live in natural habitats and non-crop areas may play an important role in augmenting and stabilizing crop yields. These bees, flies, beetles, spiders and other arthropods may spill over into the crop, and through pollination or pest control, help to improve yields, decrease inputs, and increase profitability. […]

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