In 2014-2015, there were over 100,000 hip and knee replacement operations in Canada. Among these, more than 8,500 of these procedures had to be repeated. The main cause of failure was due to bacterial infections at the surface of the implants. Furthermore, this problem is likely to get worse over time due to antibiotic resistance […]

A thorough understanding of the effects of the natural disturbances on successional dynamics is essential when developing silvicultural approaches. If applied correctly, this understanding should ensure the sustainable management of the wood resources, as well as the conservation of the biological attributes and ecological functions of forest ecosystems. With respect to the spatial and temporal […]

A thorough understanding of the effects of the natural disturbances on successional dynamics is essential when developing silvicultural approaches. If applied correctly, this understanding should ensure the sustainable management of the wood resources, as well as the conservation of the biological attributes and ecological functions of forest ecosystems. With respect to the spatial and temporal […]

La douleur arthrosique est la première cause de morbidité et de douleur chronique dans nos sociétés occidentales, source de pertes économiques et de productivité énormes. L’arthrose est aussi la maladie dégénérative la plus commune chez les animaux de compagnie et un sujet de consultation vétérinaire fréquent. Malgré des analyses extensives, l’origine et le développement de […]

La douleur arthrosique est la première cause de morbidité et de douleur chronique dans nos sociétés occidentales, source de pertes économiques et de productivité énormes. L’arthrose est aussi la maladie dégénérative la plus commune chez les animaux de compagnie et un sujet de consultation vétérinaire fréquent. Malgré des analyses extensives, l’origine et le développement de […]

Dairy cattle are exposed to stressors that negatively impact health, fertility, welfare and production. Health and climate experts predict that exposure to stressors (i.e. pathogens and extreme temperature events) will increase as climate conditions continue to destabilize. Due to increased antimicrobial resistance, there is urgent need to explore alternative strategies to promote animal health; it […]

Dairy cattle are exposed to stressors that negatively impact health, fertility, welfare and production. Health and climate experts predict that exposure to stressors (i.e. pathogens and extreme temperature events) will increase as climate conditions continue to destabilize. Due to increased antimicrobial resistance, there is urgent need to explore alternative strategies to promote animal health; it […]

Many human genetic diseases are associated with defects in post-transcriptional gene regulation and alternative splicing. Despite rapid technological advancements, successful diagnostic rates for rare genetic disorders are still low and clinical interventions and treatments unavailable for most patients. This project aims to address this challenge by developing novel antisense RNA therapies based on the splice-switching […]

Whether or not to undergo prenatal screening to assess the risk of certain genetic conditions in the fetus, and if so deciding among available prenatal screening tests, is a difficult decision faced by all pregnant women and their partners. However, few are aware of the implications of the various options. With shared decision making (SDM), […]

Un prototype de logiciel d’évaluation de l’éco-efficacité des procédés de transformations des produits laitiers par simulation numérique de procédés industriels a été développé dans le cadre des travaux de doctorat de S. Benoit. Le présent projet vise à rendre cet outil utilisable par l’industrie laitière et à l’enrichir de fonctionnalités supplémentaires. En plus de quelques […]

Glioblastoma multiforme (GBM) (the deadliest form of brain cancer) is associated with poor survival rates (approximately 12-15 months from the time of diagnosis). This is due to the fact that most cases of GBM are resistant to current standards of care. As a result, novel effective treatment options are highly desirable. It has recently been […]

Brain tumours, including ependymoma, are some of the most difficult cancers to treat. Although the past few years have seen many exciting advances in characterizing these brain tumours, there are few effective therapies available for patients, many of whom are children and young adults (and for whom long-term side effects can be extremely damaging). Until […]