Analyzing the impact of the Lactobacillus rhamnosus R0011 secretome on intestinal epithelial cell and antigen-presenting cell interactions

Intestinal bacteria are now recognized as important for maintaining our health. Many questions remain about how these probiotic or health-promoting bacteria act to influence health, and how to use them to combat the numerous health problems associated with inflammation. The objectives of this research project are to determine how products made by one of these bacteria, Lactobacillus rhamnosus R0011, influence communication between certain cells important in our immune defences, intestinal epithelial cells and antigen-presenting cells. We have found that products of L. rhamnosus R0011 can modify the behavior of these cells in ways that would reduce inflammation. Examining how the products of these bacteria influence activities of and interactions between intestinal epithelial cells and antigen-presenting cells will allow us to more accurately determine the impact on our immune defences and understand how they influence health, information of use to Lallemand Health Solutions for applications of probiotic bacteria.

Faculty Supervisor:

Julia Green-Johnson

Student:

Michael Jeffrey

Partner:

Lallemand Health Solutions

Discipline:

Medicine

Sector:

Life sciences

University:

Program: