Aeration of hydraulic turbines for increased dissolved oxygen

In warm climates warm temperatures cause thermal stratification in hydropower reservoirs inhibiting mixing and leading to deoxygenation of waters at depth (hypolimnium). Turbines withdrawing water at depth result in low dissolved oxygen (DO) in the downstream flow having a large negative impact on the downstream riverine ecosystem. Legislation in the USA and elsewhere now requires […]

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2021 Massawippi Watershed Hydrologic Flux Report of Water and Soil Quality Components

This project aims to study and assess nutrient conditions in Lake Massawippi and its surroundings. Previous studies suggest that fertilizer contaminants from various agricultural plots flow to nearby waters, especially the adjacent Tomifobia river. Our team will assess soil, and water components for net transfer of nutrient and other particle contamination. These measurements will be […]

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Research and Implementation of Haptics Device Integration With a DynamicsSimulation Engine and Applications to Milling and Drilling Force Feedback (third stage)

Virtual environments represented by multibody system models play an important role in many applications. Adding the possibility of the user directly interacting with such environments via physical touch using haptics can significantly enhance the usability and range of application of simulated environments. In this project we particularly target two main objectives: (1) the multirate-simulation and […]

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The Effect of Gut Microbiota Metabolites on Skeletal Muscle Function

Gut bacteria are increasingly appreciated as crucial actors in human physiology. Recent studies have highlighted their potential effect on muscle. For instance, endurance is influenced by the type of bacteria found in the gut. However, the precise mechanism underlying this link is still unknown. We have started to investigate the role of metabolites produced by […]

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The impact of climate change on individual and compound extreme events across Eastern Canada – Application to Intensity-Duration-Frequency curves in Labrador City

The possible failure of surface water management systems is one of the main concerns in the design, construction and management of critical infrastructures such as dams, nuclear facilities and mining activities, especially in northern latitudes. Extreme rainfall and sudden snowmelt events exert major controls on surface runoff and flooding events in cold regions such as […]

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The impact of climate change on individual and compound extreme events across Eastern Canada – Application to Intensity-Duration-Frequency curves in Labrador City – Year two

The possible failure of surface water management systems is one of the main concerns in the design, construction and management of critical infrastructures such as dams, nuclear facilities and mining activities, especially in northern latitudes. Extreme rainfall and sudden snowmelt events exert major controls on surface runoff and flooding events in cold regions such as […]

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High heat flux microprocessor cooling using binary fluid mixtures

As the heat fluxes produced by modern high-performance microprocessors continue to rise, so too must the effectiveness of the removal of these fluxes. Accordingly, a large amount of research has focused on developing techniques to enhance cooling in computer systems. A novel method of doing so involves replacing the single-phase liquid or two phase-liquid vapor […]

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High heat flux microprocessor cooling using binary fluid mixtures – Year two

As the heat fluxes produced by modern high-performance microprocessors continue to rise, so too must the effectiveness of the removal of these fluxes. Accordingly, a large amount of research has focused on developing techniques to enhance cooling in computer systems. A novel method of doing so involves replacing the single-phase liquid or two phase-liquid vapor […]

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Development of a Cell-Based Signaling Assay to Measure the Potency of a Therapeutic Antibody

Cytokines are proteins that can modulate cellular activity by binding to membrane-bound receptors or soluble receptors. When a cytokine binds to a soluble receptor, it follows the trans-signaling pathway. This signaling pathway induces unique effects on cellular activity which can drive disease progression. This proposal describes the development of a cell-based assay that can be […]

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Rapid evolution of threespine stickleback

I will examine the limits of evolution by investigating morphological and genetic variation of threespine stickleback populations in real time, under the supervision of Dr. Eric Palkovacs at the University of California, Santa Cruz. According to evolutionary theory, organisms experience selective pressures, which can result in adaptation and evolution. Since strong selection events are frequently […]

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Immunomodulatory fusion proteins to treat solid malignancies.

Immunotherapies are transforming conventional cancer treatments with significant improvement of patient survival rates. FDA-approved immunotherapies (immune checkpoint inhibitors, ICIs) have shown remarkable success in the treatment of hematologic malignancies but very low response rate in patients with solid tumors. Therefore, there is an urgent need for novel therapies against solid malignancies. Cura Therapeutics is developing […]

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