Patients who suffer from severe burns require immediate wound closure to ensure survival and facilitate healing. The current gold standard in surgical practice is the use of split-surface autographs, allographs, or skin substitutes, but limitation range from the lack of layered tissue organization, the potential for immunological rejection, and the need for high quantities of […]

The goal of neurosurgery are two folds, 1) to achieve maximal resection of the target lesions, but simultaneously 2) minimize damage to adjacent healthy brain tissues. Currently surgeons rely on preoperative images such as Magnetic Resonance Imaging to define tumor boundaries. However, the accuracy of such images decreases intraoperatively due to brain shift. For these […]

The WHO defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”. The holistic nature of this definition provides the basis for an all-encompassing evaluation of health, which is the guiding principle behind health impact assessment (HIA). An emerging area of public concern in […]

Optimizing a program for Graphics Processing Units (GPUs) is critical for performance, yet remains a challenge due to the non-intuitive interactions among the optimizations and the GPU architecture. Automatic optimization tuning for a GPU is demanding particularly given the exploding number of mobile GPU variants in the market. We explore the use of machine learning […]

Item-to-item and user-to-item recommendations are prevalent on most ecommerce websites and digital content related mobile applications. At Kobo, we strive to constantly improve our recommendation system, which is based on co-purchase patterns on Kobo’s website or through Kobo eReaders and mobile apps. This internship is to explore improving the system along several dimensions: incorporating additional […]

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) […]

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) […]

The structural performance of skyscrapers subjected to natural hazards such as strong winds and earthquakes has significant effects on the resilience of a city because of the recent boom in the construction of skyscrapers around the world. However, resilience is currently not explicitly considered in the design of tall buildings. Studies show that modern tall […]

The structural performance of skyscrapers subjected to natural hazards such as strong winds and earthquakes has significant effects on the resilience of a city because of the recent boom in the construction of skyscrapers around the world. However, resilience is currently not explicitly considered in the design of tall buildings. Studies show that modern tall […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

Antibodies are the fastest growing segment of the pharmaceutical market, and with modern engineering technologies antibodies can be programmed to target devastating diseases. Within the immune system, antibodies fight invading bacteria and viruses. High-quality synthetic antibodies directed to disease-related targets have immense therapeutic potential. Development of cell-based assays to enable rapid identification of functionally active […]