Poor drug accumulation at tumor sites negatively affects the efficacy of many anti-cancer therapeutics. Development of non-invasive strategies that can effectively monitor drug biodistribution is important, especially given the increasing number and complexity of nanotherapeutic agents in clinical development. The use of positron emission tomography in conjunction with a radiolabeled drug delivery system has the […]

As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task switching and attention. These functions are critical for the maintenance of functional independence. Few validated rehabilitation approaches for these types of deficits […]

As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task switching and attention. These functions are critical for the maintenance of functional independence. Few validated rehabilitation approaches for these types of deficits […]

The proposed project aims to investigate the pathway and mechanisms of the anaerobic biotransformation of the persistent organochlorine pesticide chlordecone (CLD). At the home institute, University of Toronto (Toronto, Canada), the intern has successfully identified a a trichloroethylene (TCE)-dechlorinating culture, KB-1, that can completely transform 1.5 mg/L (3.1 µM) of CLD within 200 days when […]

Magna International Inc., headquartered in Ontario, Canada, is North America’s largest auto parts manufacturer. It supplies automotive components and systems to nearly all global automakers, including General Motors, Ford Motor Company, Volkswagen, Daimler, and BMW. With approximately 170,000 employees across 342 manufacturing operations and 91 product development, engineering, and sales centers in 28 countries, Magna […]

In the interest of sustainability, novel aircraft configurations such as the blended-wing-body (BWB) have garnered a great deal of attention for their potential to dramatically improve aircraft fuel efficiency. The BWB concept has been studied extensively using aerodynamic shape optimization to predict its performance benefits and study the key design features of the aircraft. In […]

Musculoskeletal systems are responsible for the rich and diverse ranges of motion and behaviors exhibited by all sorts of animals, including humans. Recreating these motions is key for applications in medical simulation, robotics, and virtual reality. Unfortunately, modeling even simple control tasks such as grasping or locomotion with such musculoskeletal systems is extremely difficult. The […]

Epilepsy is a debilitating neurological disorder affecting approximately 50 million people worldwide (World Health Organization). This project proposes to develop a SMART (Seizure Monitoring At the Right Time) Headset for these patients to monitor their brain signal and track their movements, heart rates and breathing patterns. This headset will have new types of sensors suitable […]

The Bay of Quinte, a Z-shaped embayment at the northeastern end of Lake Ontario, represents a characteristic case, where scientific uncertainty underlies the current management efforts to integrate environmental concerns with socioeconomic values. The proposed project aims to develop a methodological tool that can be easily engaged with the policy practice of adaptive management and […]

The Bay of Quinte, a Z-shaped embayment at the northeastern end of Lake Ontario, represents a characteristic case, where scientific uncertainty underlies the current management efforts to integrate environmental concerns with socioeconomic values. The proposed project aims to develop a methodological tool that can be easily engaged with the policy practice of adaptive management and […]

This project explores how multilingual immigrant children aged 8–13 in Canadian ESL support programs acquire English vocabulary during their early years of settlement. Vocabulary development is crucial for academic success, yet many newcomer children face barriers that go beyond language exposure alone. The research investigates how cognitive factors, such as working memory and phonological processing, […]

Obstructive sleep apnea (OSA) is common in 10% of adults and is associated with increased cardiovascular morbidity and mortality. Furthermore, there is a 3-fold increase in OSA prevalence in fluid retaining patients such as those with heart failure. Evolving evidence suggests that fluid accumulation in the neck could narrow the upper airway (UA), increase its […]