Retrospective molecular subtyping of pediatric medulloblastomas and the evaluation of BTIC gene signature in tumors with poor prognosis

Medulloblastoma is the most common brain tumor in children. It is treated with a combination of surgical resection, chemotherapy and radiation. Radiation to a child’s brain can have harmful side effects that may have implications in later development. We intend to use molecular gene expression to classify archived tumors into 4 subgroups with associated low […]

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Targeting the RSK axis to eliminate medulloblastoma

Brain cancer is the second most prevalent cancer in children. Current treatment options are chemotherapy, radiation, and surgery, which either prolongs the child’s life for only two years or leaves them with negative side effects such as slowed development. Thus, there is a pressing need for new therapeutics. One of the focuses of our lab […]

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Toward an understanding of how YB-1 regulates drug resistance in glioblastoma multiforme through epigenetic regulation governed by BMI-1

Glioblastoma (GBM) is the most common and aggressive form of brain cancers and is the second most common cancer in children only behind leukemia. Conventional therapy consists primarily of surgery, radiation, and chemotherapy, and while these approaches have slightly improved the length of patient survival, there remains no cure for this disease. With the emerging […]

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