TREATING INFLAMMATORY BOWEL DISEASES THROUGH BLOCKING P2Y6 RECEPTOR

Extracellular nucleotides can favour inflammatory diseases via the activation of P2 receptors. The proinflammatory P2Y6 is the dominant nucleotide receptor in human and murine intestinal epithelial cells (IEC) and its expression increases during inflammation. Interestingly, we found that the blockade of P2Y6 totally prevented inflammation in the murine DSS model. This project will show whether and […]

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