Les produits pharmaceutiques font partie des traitements de santé les plus importants et les plus utilisés au Canada. Les tiers payeurs du secteur des soins de santé comme les ministères provinciaux de la santé et les assureurs privés tels que la Croix Bleue et Green Shield, utilisent divers outils et techniques pour établir un juste […]

Les chimiokines sont de petites protéines solubles appartenant à la famille des cytokines dont leurs principales fonctions sont l’attractivité et l’activation des cellules immunes. De récentes évidences suggèrent que certains membres de cette famille, dont MCP-1, sécrété au cours de la phase inflammatoire, ainsi que son récepteur CCR2, seraient également impliqués dans la genèse et […]

Le contrôle qualité de produits pharmaceutiques s’effectue par différentes méthodes telles que les tests de dissolution et les analyses de chromatographie en phase liquide à haute performance (HPLC). Comme ces méthodes sont souvent lentes et dispendieuses, l’industrie se tourne plutôt vers l’utilisation de sondes spectrales (infrarouge, Raman). Ces outils, nommés technologies d’analyse de procédés (PAT), […]

L’analyse mathématique multivariée, qui consiste en l’analyse d’une grande quantité de données, permet aujourd’hui de mieux comprendre et interpréter des processus complexes. Un type d’analyse multivariée couramment utilisé dans l’industrie est l’analyse par régression linéaire (PLS) qui permet de prédire les résultats d’un procédé à partir des différents paramètres utilisés. Bien que cet outil mathématique […]

Osteoarthritis (OA) is a common disease in middle-aged and older Canadians attending primary care practitioners. As the Canadian population ages and with increasing obesity, OA will become an increasing burden for individuals and the health care system. Given the potential of Electronic Medical Record (EMR) data for surveillance of the population that is at high […]

Pharmaceuticals are among the most commonly used and important healthcare treatments in Canada. Third party healthcare payers, such as provincial departments of health and private insurers such as Blue Cross and Green Shield, use a variety of tools and techniques to balance the access, cost and quality of medications. Collectively, these tools and techniques are […]

This project will profile the use of new drugs of rheumatoid arthritis, in a population-based sample. Potential differences in the use of these agents will be examined to identify discrepancies in drug use patterns across demographics, which could be addressed through targeted strategies. Our proposal is timely in terms of increasing attention on the part […]

  Arthritis is a debilitating disorder characterized by chronic inflammation and persistent pain. This project aims to uncover ways of reducing the pain and discomfort felt by people afflicted by this disorder.  A number of key points will be addressed through this project. Firstly, we will gain a better understanding of the possible neurological component […]

Decision-making frameworks for Health Technology Assessment (HTA) have become a major topic in developed nations in recent years. Indeed, the quest for more rational and transparent HTA decision led many jurisdictions to investigate the use of Multi-Criteria Decision Analysis (MCDA) as an alternative decision-making framework. In Canada, the development of a MCDA framework for HTA […]

Clostridium difficile infection (CDI) has become the leading cause of hospital acquired nosocomial diarrhea worldwide. The prolonged hospital stays associated with CDI has enormous impact on the healthcare systems in terms of costs and patient outcomes. While treatment of CDI is an important area for ongoing research, prevention efforts will need to be enhanced to […]

Following the study of spinal cord transected (SCT) rat models being treated by fesoterodine fumarate (antimuscarinic drug) to prevent neurogenic detrusor overactivity, bladders of all 30 animals were conserved. It was observed that an early fesoterodine fumarate administration at the time of transection modulates bladder overactivity. However, the exact mechanism of action is not known […]

Pharmaceutical companies are required to perform stability testing of their drug products by regulation. A drug product that succeeds on stability testing means that its identity, potency, and purity remain within pre-established limits over its shelf life. Nowadays, drug products are more frequently reformulated in response to a highly competitive market, new research discoveries and […]