Understanding Stress Signaling in Childhood Cancers: ROS signaling pathways

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused on elucidating the genetic and biological determinants of the metastatic process in childhood cancer. Metastatic disease remains the single most dominant driver of adverse outcome in most childhood cancers, particularly in childhood sarcomas. There are two basic strategies in the program for studying metastatic disease […]

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Role of ROS regulation by Hace1 in modulating “stemness” versus differentiation of stem cells

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused on elucidating the genetic and biological determinants of the metastatic process in childhood cancer. Metastatic disease remains the single most dominant driver of adverse outcome in most childhood cancers, particularly in childhood sarcomas. Cancer stem cells, malignant cells that share many characteristics with normal stem […]

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