Antibodies are the fastest growing segment of the pharmaceutical market, and with modern engineering technologies antibodies can be programmed to target devastating diseases. Within the immune system, antibodies fight invading bacteria and viruses. High-quality synthetic antibodies directed to disease-related targets have immense therapeutic potential. Development of cell-based assays to enable rapid identification of functionally active […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

Mental Health First Aid (MHFA) training is a 12 hour course that was developed in 2001 for health care workers to better support clinical patients in mental health crisis. Evaluations of the training indicate that individuals who take this training improve knowledge of mental health disorders (e.g., psychotic disorders) and are better able to provide […]

Better light collection by photodetectors would automatically improve signal to noise ratio and photodetector performance. For example, for the positron emission tomography application, it would result in a better image quality for a lower dose. The main cause of the light loss is too much reflection of light that is trying to travel from the […]

Since the beginning of recorded time, humans have been developing ways to make themselves more beautiful or otherwise change their appearance. The hair-care industry itself has a huge global economic power: its estimated total value is $47B annually. However, beauty does not come without a price: methods currently being used for hair colouring and styling […]

Future cellular systems must accommodate increasing demand for very high throughput and low latency data services. Massive multiple-input multiple-output (MIMO) approach involving base stations equipped with much larger numbers of antennas than the numbers of users served promises to significantly increase network capacity, while nonorthogonal multi-carrier transmission is expected to dramatically reduce the latency. Integration […]

Community integrated energy and food systems bring production and management to the local scale in order to increase autonomy and resiliency. These are particularly expedient in the face of global climate change, more frequent and severe extreme weather, geopolitical instability and peak oil. Bioenergy systems offer enormous potential for such applications because they stand at […]

Prostate cancer will affect 1 in 7 Canadian males. While the number of therapeutic options is increasing, matching each patient to the right therapy remains as the challenge for a personalized approach to patient management. Currently, most of the attention has focused on identifying biological tags that can predict patients response. We have developed an […]

Large northward-flowing boreal rivers are an important hydroelectric resource, but effects of river regulation on downstream geomorphology and aquatic ecosystems are difficult to predict. Peace River, BC presents an ideal case study of river response to regulation, with continuous monitoring since dam construction in 1967. However, current understanding of system changes is based mainly on […]

Several fish species produce species-specific sounds that can be identified in the wild using Passive Acoustic Monitoring (PAM) (i.e. dataloggers configured with underwater microphones). Our project will use existing and new PAM recordings to monitor the distribution of several fish species in the western Canadian Arctic, with particular focus on a keystone Arctic species, the […]

The successful commercialization of new cathode materials for lithium ion batteries requires an improved and detailed understanding of the correlations between their structure, properties, and performance. Such a correlation will provide a foundation for better understanding the degradation mechanisms and optimized operating conditions for these cathode materials; pairing new battery materials with ideal applications and […]

The scope of this project is to use acoustic data from long-baseline arrays of hydrophones to detect, locate, and track marine mammals based on their vocalization. Specifically, the project aims to assess methods and develop automated tracking algorithms that provide accurate results for individual signals, and a maximum of flexibility regarding the channel, array, and […]