La leucémie est le cancer le plus commun chez l’enfant. Elle est déclenchée par des abbérations génétiques dans des cellules très productives dans le système hématopoïétique; ainsi, ces mutations causent une accumulation de globules blancs immatures dans le sang et les tissus. De nouveaux traitements immunothérapeutiques sont sous étude pour remplacer la chimiothérapie cytotoxique. Un […]

One major challenge in studying holdfast bioadhesive properties is that cells synthesize only a very small quantity of holdfast at one pole of the cell. Therefore, all studies of holdfast bioadhesive properties have been conducted by atomic force microscopy (AFM). While AFM is a powerful technique, any development of holdfast for practical applications will require […]

Durant ce stage, l’objectif est d’étudier le flux de patients entre les urgences et l’hôpital. Nous allons présenter un modèle de simulation afin d’analyser le parcours des patients dans les urgences, entre les urgences et l’admission et les urgences et le congé. Nous visons d’identifier les causes des problèmes de congestion dans les urgences retardant […]

Embedded in the surface of a virus, are different types of proteins that the virus uses to enter a host cell. These so-called viral glycoproteins are pivotal targets of the host antibody response to fight a viral infection. In recent decades, it has become clear that certain viral glycoproteins have evolved clever ways to suppress […]

Parkinson’s disease (PD) is a devastating neurodegenerative disease impacting the nervous system and resulting in a wide range of symptoms including characteristic motor impairments such as tremor, slowed movement and muscle rigidity. It is an age-related disease affecting 1% of the population over the age of 60. Although symptomatic treatments are available, there are no […]

Electromagnetic (EM) waves are becoming more prevalent due to the rapid development of electronics, which pose serious risks to human health, electric devices, and the environment1,2. In order to overcome the above problems, engineering and fabrication of multifunctional EM shielding materials are indispensable. Thus, recently, a wide spectrum of materials ranging from metals to soft […]

De nombreux problèmes décisionnels réels issus des domaines des transports, de la logistique et de l’administration publique partagent une structure commune dans laquelle un décideur cherche à adopter des politiques permettant d’optimiser un objectif qui dépend de la réaction d’une population. Pour adéquatement formaliser ce type de problème, l’hétérogénéité des préférences et des objectifs des […]

Decomposition is the dynamic process whereby a compound is disintegrated into its elementary constituents through physical, chemical and biological mechanisms. Matrices associated with decomposing human remains, such as soil, are an omnipresent source of physical evidence in forensic casework. Previous research has already emphazied the use of these matrices to evaluate their potential to capture […]

ZrB2-B4C composites are potentially very attractive for aerospace applications exposed to ultra-high temperatures > 2000 degree C. While monolithic composites in this material system are well-known, development of a functionally graded composite (FGM) is a novel idea. Recently, we have published a research article [1] in which the FGM concept in this system has been […]

Today’s wind energy prediction procedures ignore the flow deceleration, also known as blockage, caused by the wind farm on the approaching wind, resulting in a power overprediction bias that pervades the entire farm. Numerical large eddy simulations (LES) of wind farms immersed in atmospheric boundary layers (ABL) will be used to study the phenomenon and […]

The aim of the project is to develop microfluidic technologies to analyse heterogenous tumor tissues/cells via a multi-modal approach using spatial genomic, transcriptomic and proteomic data. The resulting data obtained could be used for prognostics, diagnostics and prediction of therapies. Microfluidic scanning probes (MFP) technology, invented by the Kaigala team while at IBM Research in […]

Messenger RNAs (mRNAs) need to be decoded and translated into proteins in our bodies. This process must be tightly regulated by RNA-binding proteins such as LARP1. This protein is found in several organisms and by regulating mRNA translation it also regulates cell growth, but its function is poorly understood. LARP1 has been found in higher-than-normal […]