Disorders of ovarian function are major causes of infertility, subfertility and cancer in mammals. For this reason, our research interest is the study of ovarian physiology and dysfunction; particularly the regulation of ovarian follicle development and ovulation in cattle. Recently, we generated considerable insight into the regulation of a completely novel signaling pathway during ovarian […]

Russian invasion of Ukraine began in February 2014 after Russia’s illegal annexation of Crimea. A larger invasion took place on February 24, 2022. Both conflicts have caused the displacement of 8 million Ukrainians to date. This is the largest humanitarian crisis in history since World War II. A significant percentage of these Ukrainian refugees have […]

En 2011, le test génomique prénatal non invasif (TGPNI) a permis d’analyser l’ADN fœtal dans le sang maternel pour dépister efficacement la trisomie 21. Présentement, le système de santé public rembourse ce test dispendieux uniquement pour des individus déjà dépistés à haut risque par des tests biochimiques moins performants. Ce projet vise à informer les […]

Les ordinateurs quantiques promettent de réaliser des calculs et des simulations en manipulant l’état quantique de particules. Ainsi, le développement de cette technologie demande de concevoir des systèmes pouvant réaliser ces manipulations. Dans les dernières années, plusieurs modèles ont été proposés pour permettre le déplacement d’états quantiques. D’autres ont aussi été proposés afin de créer […]

Alkynamides are very promising inhibitors of tyrosine kinases, important enzymes that can cause cancer when being too active in cells due to different mutations. While being important moieties, until recently there was no convenient method to synthesize them using carbamoyl fluorides — most protocols use either dangerous or expensive and ecologically unfriendly reagents, which always […]

T cells are specialized immune cells that protect us against infection and cancer. These cells express a molecule (known as the T cell receptor, or TCR) which recognizes a small portion of foreign or abnormal proteins presented on the surface of infected or cancer cells. The interaction between the TCR and this small protein fragment […]

Building software systems is a complex task. Teams of developers must gather and exchange large quantities of technical and conceptual information to build reliable systems. This transfer of knowledge is mainly supported by tangible documents that contain information deemed important for different contexts. However, determining what information is important is itself challenging. The importance should […]

Acute lymphoblastic leukemia (ALL) is the most common hematological cancer in children. 10 to 15% of pediatric cases are of T cell origin (T-ALL). Current intensive multidrug therapy can achieve high cure rates, yet associated with serious long-term adverse effects, including secondary cancers. Moreover, 15% of children will relapse, facing a poor prognosis. We previously […]

Pour appuyer l’ingénieur lors de la conception, un nouvel outil d’optimisation structurelle basé sur l’apprentissage profond sera conçu afin de diminuer le temps requis pour générer des concepts préliminaires. Cet outil tirera profit des récentes percées dans le domaine de l’apprentissage par renforcement profond, afin d’entraîner un agent décisionnel autonome à accomplir la tâche d’optimisation. […]

Les personnes vivant avec un spina-bifida et/ou l’hydrocéphalie (SBH) font face aux enjeux du vieillissement pouvant complexifier les défis de participation sociale. Or, les besoins associés à ces transitions demeurent méconnus et peu de ressources existent. L’Association de spina-bifida et d’hydrocéphalie du Québec (ASBHQ) souhaite accompagner ses membres, leurs proches et les intervenants pour promouvoir […]

During uterine involution (occuring after giving birth), the uterus sustain diverse morphological and inflammatory changes to eliminate the potential contamination of the uterus and prepare for a subsequent pregnancy. In cows, a failure to eliminate a potential uterine contamination after giving birth could lead to endometritis, a disease characterized by persistent inflammation of the uterine […]

The project aims to understand the molecular mechanisms by which the Ankle2 protein functions to allow nuclear reformation after mitosis. This process is frequently disrupted in cancer cells, which induces an innate immune response that could be exploited in therapies. A multidisciplinary approach in the Drosophila model will be used.