Improved data driven sgRNA design for use in bacteria

CRISPR/Cas9 is a promising tool for genome engineering in bacteria, but it’s limited by inconsistent accuracy. Though some studies have been conducted to understand why this inconsistency occurs, many important biological features have not been explored. Moreover, computer based attempts to predict accuracy have suffered from these knowledge gaps. This is due mainly to the […]

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Clinic@Joe’s Associate

We would like to hire one MBA student for their business knowledge and skills to support market analysis, intellectual property research, competitive and regulatory landscape analysis, as well as funding opportunities for early stage drug and technology development within Research St Joseph’s Hamilton (RSJH). The MBA student will work on diverse projects and get familiar […]

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Fire resistance behavior of FRP reinforced concrete slabs

Pultrall produces FRP bars for several applications in the construction industry. Although the advantage of using advanced materials in civil engineering is outstanding, the company needs more information regarding the performance of its product in fire. Material tests will be conducted on FRP bars at high temperature and full-scale fire tests on FRP reinforced concrete […]

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Development of a Simulation Pipeline for Validating and OptimizingElectrically Tunable Liquid Crystal Zooming Systems

[Reseach Abstract. Project Overview missing] simulation package available) to simulate a zooming system composed of tunable liquid crystal lenses that is capable of aberration correction. The first component of the project consists of simulating a liquid crystal lens in COMSOL. The liquid crystals rearrange themselves based on a space varying electric field created by the […]

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Evaluation of recombinant bovine herpes virus-1 as a platform for novel cancer immunotherapy development

The most recent breakthroughs in cancer treatment are based on understanding that our immune system can be activated to attack tumours. While first achieved using antibody drugs called “checkpoint inhibitors”, this new paradigm of activating a cancer patient’s own immune system is also possible using viruses, an emerging field known as oncolytic virus (OV) therapy. […]

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100% Canadian Sourced Enhanced Antiviral Medical Masks for COVID-19 and PPE Innovation

The COVID-19 pandemic has created supply chain issues for medical masks worldwide. There is clearly a need for mask manufacturing and material sourcing capabilities in Canada. This proposal is a partnership with Feedband Labs to develop an enhanced ASTM 2-3 equivalent, antiviral medical mask that can be strategically sourced and produced in Canada. The 4-layer […]

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Assessment, Piloting and Establishment of a Green Health Care Revolving Fund to Enhance Implementation of Energy Efficiency Projects at Health Care Facilities

The objectives of the research is to identify and quantify barriers to energy efficiency in Ontario Hospitals, to identify methods to confront these barriers, including through the use of revolving funds, and to provide a case study by designing, implementing and measuring the results of a revolving fund to be set up for the Hart […]

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Security Analysis of POLARIS

Blockchain and distributed ledger technologies provide networks a method to ensure trust in the network while not relying on a central authority, or even any individual node in the network. Moreover, these technologies enable secure transaction and recording keeping within the network by using distributed consensus to verify the actions of users and cryptographically linking […]

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Accelerated and sensitive detection of (bio)chemical analytes through active capture on Surface-enhanced Raman scattering (SERS) chips

Surface enhanced Raman scattering (SERS) is emerging as a promising technique for rapid, ultrasensitive and highly specific (bio)chemical detection. SERS has been successfully used for the detection of minute quantities of illicit drugs, food contaminants, environmental pollutants, even bacteria and viruses. Unfortunately, like most other surface-based detection methods, SERS also suffers from the same bottleneck, […]

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Architectural and Design Modelling for Blockchain-Intensive Systems

Blockchain technologies are increasingly becoming integral parts of information systems in domains that exhibit an increased need for resilience and can make no assumption of trust between parties. However, properly adopting blockchain in an information system design remains difficult, unsystematic and requires thorough understanding of the technology. In this project we explore ways by which […]

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Application of time-frequency based techniques to assess Auditory Brainstem Responses in newborn hearing assessment

Automatic detection and classification of the Auditory Brainstem Responses (ABR) is used in newborn hearing screening. Improved detection algorithms will reduce test time, prevent infants with hearing loss from being missed while reducing the number of normal hearing babies referred to diagnostic testing. We have already improved the objectivity of ABR classification in neurological assessments […]

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Helping Ontario Meet its Environmental Goals- Hydrogen Adoption report for Ontario

Hydrogen technology in Ontario has incredible potential as an alternative energy source that can eliminate the use of harmful fuels and greatly reduce greenhouse gas emissions. Canada is currently developing a nation-wide strategy to increase the adoption of hydrogen technology; however, Ontario is underrepresented in this discussion. Science Concepts International will work with its interns […]

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