Heart disease bears a heavy burden on the health care system. Curative approaches are extremely limited and surgery is often the best course of treatment. Heart disease encompasses a variety of disorders, but among these, myocardial infarction (MI), or a heart attack, presents an especially difficult case for treatment. MI is caused by destruction of […]

Currently, over 95% of new anti-cancer drugs fail during clinical trials (1). Despite significant technological advances, drug development has become slower and more expensive. The root cause is that current preclinical cancer models, such as 2D cell layers and animal models, fail to accurately recreate human biology. This makes it very difficult to predict how […]

Diagnostics are critical to our healthcare infrastructure, with substantial impacts on patient care and public health policy. Proteins have been used as diagnostic markers for disease monitoring for nearly 200 years, however, current analytical methods require expensive equipment and expert technicians. This restricts the use of such methods to centralized laboratories where they process samples […]

Treatments for neurodegenerative disorders represent an unmet medical need, affecting more than 50 million people worldwide. Through extensive research, we have identified two innovative therapeutic targets that have demonstrated promising effects in enhancing the regeneration and resilience capacities of neurons in animal models of Amyotrophic lateral sclerosis and Huntington’s disease. Our approach not only has […]

Phytopathogenic fungi secrete diverse enzymes to help them infect host plants. Foliar phytopathogens like Colletotrichum species, contain tandem copper radical oxidase (CRO) and peroxidase genes. The CRO-peroxidase pair is co-secreted during initial leaf penetration phases. The CRO oxidizes long-chain alcohols found in the leaf cuticle while the peroxidase activates the CRO. We discovered that the […]

The challenges posed by yield loss and plant diseases facing climate change are on the rise. And it is impossible to ignore fungal pathogens in agriculture. Sclerotinia sclerotiorum is one of the most devastating plant pathogens that can cause substantial damage to major crops such as canola, various beans, and sunflowers in Canada, the USA, […]

The proposed research project at the Turak Functional Nanomaterials Research group at Concordia aims to enhance the efficiency of solar energy data measurement and analysis from emerging solar cell technologies. In a world increasingly focused on sustainable energy sources, efficient utilization of solar power is paramount. The lab manages vast data, including complex images of […]

The proposed research project aims to investigate how Saccharomyces cerevisiae, a microorganism commonly used in the food and biofuel industry, responds to changes in temperature and manages to withstand high temperatures. Yeast cells face various types of stress as the environment conditions change, both in natural situations and during industrial processes. S. cerevisiae has developed […]

Triple negative breast cancer (TNBC) is a highly invasive and heterogenous disease that does not express oestrogen receptor and progesterone as well as the human epidermal growth factor receptor-2 and accounts for approximately 20% of all breast tumors. Its heterogenicity makes unlikely to reach the complete TNBC patient population with a single therapeutic agent. Therefore, […]

The major problem with intervention for schizophrenia is the inability to treat all symptom categories (positive, negative, and cognitive) sufficiently. The need to test new novel therapies is crucial, which may prevent the onset of this debilitating disorder. Since intervention is limited to individuals at high risk, researchers have turned to animal models to test […]

ace à la propagation alarmante des bactéries résistantes aux antibiotiques, le développement de nouveaux antimicrobiens avec des modes d’action innovateurs est devenu une priorité mondiale. Parmi les différentes alternatives, les peptides antimicrobiens d’origine bactérienne comme les bactériocines sont très prometteurs. Ce projet s’intéresse particulièrement à cinq bactériocines produites par la bactérie Lacticaseibacillus paracasei qui ont […]

Cancer is associated with an accumulation of alterations in genes that confer the ability of cancer cells to grow uncontrollably. These alterations can contribute to increased deleterious function or loss of function of genes that normally regulate cell growth. Genes in our cells are organized on chromosomes which duplicate every time a cell divides. In […]