This proposed research builds on my current PhD thesis research, where I have characterized and validated a micro-tissue engineering platform that can be used to efficiently generate pancreatic islet-cell clusters (“pseudoislets”) that have significantly increased insulin secretion capacity, and superior capacity to reverse diabetes in animal studies. These findings have suggested a strong therapeutic prospect […]

Il y a peu de traitements efficaces pour réduire les symptômes de douleur associés à l’arthrose. Ceci est en partie dû à nos connaissances limitées sur le sujet. Plusieurs modèles ont été développés et celui qui se démarque est celui de l’injection intra-articulaire de mono-iodoacétate (MIA). Bien que le modèle de MIA chez le rat […]

Glucose monitoring has improved significantly over the last few years. Devices have become smaller, and today wireless wearable devices offer a seamless solution for people who require to monitor their glucose level multiple times daily. However, wearable devices are not always well accepted by people. Furthermore, monitoring solutions that are completely autonomous face acceptability issues […]

Cannabis sativa is a plant well-known for its production of cannabinoids, which are lipids with unique pharmacological properties. These compounds are produced mainly in female floral buds in specialized epidermal outgrowths known as glandular trichomes. These structures consist of a long stalk supporting a disk of biosynthetically active cells that produce the cannabinoids. Cannabinoid biosynthesis […]

The main goal of this research project is to understand how the consumption of fructose can lead to the developement of hypertension. Hypertension is one of the most world spread health condition and a major risk factor for cardiovascular diseases, stroke and death. The high presence of fructose in the body, whether directly due to […]

Hearing aids are a common form of treatment for individuals suffering from a hearing impairment [1]. These devices work by collecting sound from the surrounding environment and amplifying that sound in the patient’s ear to improve hearing [2]. These devices work well under most conditions however, in noisy settings such as a busy restaurant, hearing […]

Diphtheria is still a disease causing significant morbidity and mortality in people worldwide that did not received vaccination or suffer from incomplete immunization. The disease is due to a powerful toxin produced by the pathogenic bacterium Corynebacterium diphtheria. A good vaccine already exists but its production is rather complex and involves several steps: cultivation of […]

Immunovaccine Inc. is developing cancer vaccines using the company’s DepoVaxTM vaccine technology. DepoVax is a patented formulation that displays excellent tumor control and provides a long lasting and specific effect. The way by which this vaccine exerts its effect is unclear but the translational team at Immunovaccine is determined to discover its mechanism of action […]

Chronic heart failure (HF) is an epidemic affecting approximately 1.5-2% of Canada’s population (12% in patients over 80yrs) and the current one-year mortality rate after HF diagnosis remains disturbingly high at 25-40%. Even with treatment, many HF patients require hospitalizations during the course of their disease; in Canada HF is responsible for $3 billion in […]

The project involves the modeling of the metabolism of TB. I developed an algorithmic pipeline called MetaMerge, which allowed me to reconcile differences in format, nomenclature, and annotation, between two models of TB metabolism. MONGOOSE, another doctoral project of mine, is a tool for analyzing metabolic network models in exact arithmetic, resulting in consistent, reproducible […]

Body composition, i.e., the proportion of fat and muscle tissues in the human body is related to the risk factors associated with a host of medical conditions. The muscle and fat tissues are target locations for the water- and fat-soluble drugs respectively used for cancer treatment. Consequently, the proportions of these tissues are believed to […]

The first step is reviewing what has already been done in the lab and around the globe. Then we will Identify the biomarkers to target and techniques that can be used to do so. Next is to design a device in such a manner that the desired interaction is happening for efficient sensing of the […]