Chronic heart failure (HF) is an epidemic affecting approximately 1.5-2% of Canada’s population (12% in patients over 80yrs) and the current one-year mortality rate after HF diagnosis remains disturbingly high at 25-40%. Even with treatment, many HF patients require hospitalizations during the course of their disease; in Canada HF is responsible for $3 billion in […]

The project involves the modeling of the metabolism of TB. I developed an algorithmic pipeline called MetaMerge, which allowed me to reconcile differences in format, nomenclature, and annotation, between two models of TB metabolism. MONGOOSE, another doctoral project of mine, is a tool for analyzing metabolic network models in exact arithmetic, resulting in consistent, reproducible […]

Body composition, i.e., the proportion of fat and muscle tissues in the human body is related to the risk factors associated with a host of medical conditions. The muscle and fat tissues are target locations for the water- and fat-soluble drugs respectively used for cancer treatment. Consequently, the proportions of these tissues are believed to […]

The first step is reviewing what has already been done in the lab and around the globe. Then we will Identify the biomarkers to target and techniques that can be used to do so. Next is to design a device in such a manner that the desired interaction is happening for efficient sensing of the […]

L’immunothérapie est un traitement prometteur pour soigner le cancer et les infections virales. Ce traitement consiste à éduquer des cellules du système immunitaire, les lymphocytes T, pour qu’ils puissent éliminer les cellules problématiques du patient. Une des grandes difficultés est de fournir de l’aide spécialisée aux lymphocytes T pour faire leur travail. Cette aide vient […]

Le projet consiste en un stage de recherche en biologie synthétique, un domaine scientifique émergeant reliant biologie et ingénierie afin de construire ou modifier des systèmes biologiques dans le but de répondre à certaines problématiques. Les maladies infectieuses sont des causes de pertes économiques majeures à l’échelle du globe, entre autres dans l’industrie agroalimentaire. Le […]

The objective of the project is to implement the fiber optics devices developed at Polytechnique Montreal inside the surgical robots used at Johns Hopkins University to improve the accuracy of the shape sensing reconstruction to possibly replace the ones currently used in those robots. These devices could be more effective since they rely on a […]

The Black Queen Hypothesis is a novel theory in reductive evolution that suggests while some metabolic functions must remain in the cell, others can be outsourced to the surrounding community. Phytoplankton are important members of marine ecosystems, and many exist in symbiotic relationships with co-occurring bacteria. Phytoplankton produce reactive oxygen species (ROS) as a by-product […]

Continuous blood pressure (BP) monitor is highly beneficial for detection and prevention of stroke and cardiovascular disease. The most common BP monitor technique still relies on using a cuff that slows the blood flow, which is both uncomfortable and makes continuous monitoring impossible. Furthermore, research has shown that due to the numerous artifacts, the existing […]

The generation of functional ?-cells from human pluripotent stem cells (hPSCs) for cell replacement therapy and disease modeling of diabetes is a strongly investigated area. Recent scientific breakthroughs have enabled derivation of large quantities of human pancreatic ?-like cells in the laboratory, but the protocols are currently not consistent or optimized for cells of various […]

Magnetic resonance imaging (MRI) is an imaging modality which can visualize the internal structure of the human body and is free of radiation. In this project, we would like to write a multi-functional and robust MRI software package using ultrashort echo time (UTE) technique to realize the imaging of the tissues, such as tendons, ligaments, […]

The last 5 years have seen remarkable advances in speech, image and language recognition tools that have been made available to the public through computer and mobile devices’ applications. Some of these significant improvements were achieved by an artificial intelligence tool known as deep learning (Hinton et al., 2006) that generally refers to a set […]