La tomographie d’émission par positrons (TEP) est une modalité d’imagerie médicale permettant le diagnostic et le suivi de cancers, maladies neurodégénératives et maladies cardiométaboliques. La prochaine percée majeure en imagerie TEP repose sur la mesure de temps-de-vol (TdV) ultra-rapide, nécessitant une excellente résolution temporelle des détecteurs du scanner. Les détecteurs conventionnels ne possèdent malheureusement pas […]

Airborne pathogens can easily and quickly spread respiratory diseases. Devices currently used for protection in hospitals, such as N95 respirators, rely only on filtration. Additionally, surgical masks have been increasingly used, although not effective against aerosols. This has been observed during past pandemics and epidemics of severe acute respiratory syndrome (SARS), swine flu, and Middle […]

Glutamate, the most widespread excitatory neuromediator in the brain, plays an important role in learning and memory functions. At very high cerebral concentrations it is likely to cause pathological effects (nerve cell death), such as those encountered in ischemic stroke. To reduce the toxic concentrations of glutamate in the brain, several approaches have been developed. […]

The goal of this project is to further develop the JGI technology CRAGE, which enables the insertion of large DNA fragments into the chromosome of a host organism. Over the course of the 3 months, the CRAGE system will be adapted for the E. coli EPI300 strain that is host to the Hallam Lab functional […]

My research has focused on optical nanoantenna-based plasmonics for achieving improved performance in optical applications. Recently, I have researched on energy transfer through nanoantenna waveguides and nanopixel color presenting with nanostructures. I have also systemized the optical setups including EOT/SPR biosensor, plasmonic lithography, and I have working on multichannel imaging system. During the visit, I […]

This project aims at evaluating whether recent results in deep learning models, trained to exploit weak labels (Hwang, 2016) can serve to extract meaningful lesion localizations from image-level labels, either from individual scans or given a (longitudinal) sequence thereof. To this end, we will scale up existing models that have been shown to work on […]

L’herpèsvirus humain 6B (HHV-6B), virus de la roséole, infecte près de 95% de la population avant l’âge de deux ans. Il est connu qu’HHV-6B intègre son matériel génétique aux télomères de la cellule qu’il infecte, régions des chromosomes qui contrôlent la durée de vie des cellules. Il est anticipé qu’une insertion d’HHV-6B à cet endroit […]

Craniofacial fractures require stabilization to restore appearance, facilitate healing and improve patient’s outcomes. The current standard of care is rigid titanium plates, which require drilling, screws and bending of titanium plates with plyers during surgery to conform to the complex geometry of the face. This is an over engineered solution that is not only difficult […]

Increased awareness of the issues associated with using opioids such as morphine that target the mu-opioid receptor – namely, that these drugs tend to lead to dependency and significant, often life-threatening, side effects – have led researchers to identify the delta opioid receptor as an alternative, and potentially safer, target for the management of chronic […]

Le projet consiste en la conception et l’utilisation de modèles cellulaires et animaux de cancers et fibroses, notamment de tumeur cérébrale, pour l’étude de l’hypoxie tumorale. Les techniques d’imagerie par résonance magnétique et de tomographie à émission de positrons seront utilisées pour réaliser l’étude. La manipulation de la radioactivité afin d’obtenir des images scintigraphiques sera […]

Cancer cells are nearly impossible to distinguish from normal tissue without sophisticated detection methods and conventional methods fail to provide real-time information during the surgical procedure. ODS Medical is developing an exclusive Raman spectroscopy system that collects data through an optical probe and is interfaced with sophisticated machine learning algorithm to identify tissues abnormalities in […]

Tissue engineering works to replace damaged tissue and organs, and has applications in treating diseases such as diabetes. To improve the performance of tissue engineering treatment and research, our lab has produced the microwell system which creates microtissues in the form of cellular balls. The microwell system has been used used internationally under the brand […]