Increased awareness of the issues associated with using opioids such as morphine that target the mu-opioid receptor – namely, that these drugs tend to lead to dependency and significant, often life-threatening, side effects – have led researchers to identify the delta opioid receptor as an alternative, and potentially safer, target for the management of chronic […]

Le projet consiste en la conception et l’utilisation de modèles cellulaires et animaux de cancers et fibroses, notamment de tumeur cérébrale, pour l’étude de l’hypoxie tumorale. Les techniques d’imagerie par résonance magnétique et de tomographie à émission de positrons seront utilisées pour réaliser l’étude. La manipulation de la radioactivité afin d’obtenir des images scintigraphiques sera […]

Cancer cells are nearly impossible to distinguish from normal tissue without sophisticated detection methods and conventional methods fail to provide real-time information during the surgical procedure. ODS Medical is developing an exclusive Raman spectroscopy system that collects data through an optical probe and is interfaced with sophisticated machine learning algorithm to identify tissues abnormalities in […]

Tissue engineering works to replace damaged tissue and organs, and has applications in treating diseases such as diabetes. To improve the performance of tissue engineering treatment and research, our lab has produced the microwell system which creates microtissues in the form of cellular balls. The microwell system has been used used internationally under the brand […]

The hormone insulin rises in the blood after consuming food. Too high of an insulin response may be a sign of dysfunctional metabolism and has also been shown to promote weight gain. Thus, if insulin levels rise too high after a meal it may indicate that someone is metabolically unhealthy or is prone to obesity. […]

Phytoene is a colorless carotenoid that absorbs light in UVA(286nm). It has powerful antioxidant and UV blocking effect and is used as a useful cosmetic material that can cope with the urban aging of skin in modern people. The purpose of this study is to construct and optimize phytoene biosynthetic pathway using E. coli. To […]

-Lemon Aspen is an indigenous plant of Uncandy and its extract contains terpenes (FPA and its derivatives) which have high efficacy such as skin whitening, pore contraction, anti-inflammatory, antioxidant, anti-inflammatory and antibacterial. -It is necessary to develop production technology based on biological process in order to solve the problem of delays in commercialization because it […]

Gut microbiome stability appears to be essential for keeping health nowadays. Then, the needs to develop proper tools to modulate microbiome become important issue. In this proposal, we suggest predatory bacteria as microbiome modulator. Predatory bacteria are ubiquitous in the environment and non-toxic to mammalian cells. Recent researches proved the existence of predatory bacteria inside […]

Dysfunctions of the placenta leads to a serious pregnancy associated disease of the mother called preeclampsia (PE) and certain forms of fetal growth restriction (FGR) that are hard to treat or prevent. Our laboratory has shown that overproduction of decorin, a molecule made by the pregnant uterus, leads to placental defects resulting in PE and […]

Sea cucumbers are found in both benthic areas and deep seas and have been used as a source of food and drug for decades. During the past decade, several scientific research initiatives explored various species of sea cucumber. However, not much research has been done on Atlantic species. As an emerging fishery in Atlantic Canada, […]

Ibuprofen is at the top of the World Health Organizations listing of essential medicines. As such, Ibuprofen is commonly consumed in nearly all countries. Considering Ibuprofen is poorly degraded by the human metabolism, wastewater tends to be a significant source of Ibuprofen in the environment. Concern has arisen over the past decade due to Ibuprofens […]

Genetic engineering has proven to be a useful approach for gene therapy and transformation of value-added agricultural plants. However, the current available technologies suffer from several limitations. These include relative low delivery efficiency with difficult-to-deliver cells or complex constructs and limit freedom-to-operate. Considering advances have been made in the applications of nanotechnology to life science […]