In recent years there has been a growing focus on evaluating the reproducibility of scientific findings. In neuroimaging this has been explored with respect to the impact specific choices in analysis software have on the resulting claims and their ability to be replicated across datasets or other tools. The focus of my Ph.D. involves the […]

Combating infectious disease pathogens is a pressing global health challenge. Due to limited treatment options, fungal pathogens pose a unique challenge, and are emerging as a leading cause of human mortality. Focusing on Candida albicans, the most common cause of fungal infections, our research project aims to understand how different genetic factors play a role […]

Enzymes are important biological catalysts which span all domains of life. They play vital roles in the metabolism and production of biomolecules in different organs. Our interest lies in using enzymes to develop biosensors to be employed in studying neurochemical processes occurring in the brain. The purpose of this project is express and characterize three […]

Ovarian cancer (OVCA) causes more death than any female cancer in the world. Although patients respond to treatment initially, 70% of them relapse and do not succumb to treatment. Up-to-date, there is no established treatment for such patients. There is therefore the need to investigate the tumor microenvironment for novel targets to enhance treatment. Although […]

The Rett syndrome is a progressive neurodevelopmental disorder and one of the most common causes of mental retardation in females. Because males have a different chromosome combination from females, most males with Rett syndrome die before birth or in early infancy. It was not until 1999 that it was discovered that the Rett syndrome is […]

es dernières années, les objectifs imposés par la gouvernance environnementale internationale ont conduit au développement de matériaux plus durables. Au Canada, cela a permis l’essor de nouveaux produits technologiques issus de l’industrie agroforestière et en particulier la valorisation de la cellulose pour le développement de nouveaux matériaux ‘vert’ à faible impact environnemental. Parmi les différents […]

Alzheimer’s disease (AD) is thought to be caused by accumulation of protein, called “beta-amyloid” in the brain. This protein has been shown to accumulate on the surfaces of brain cells, deforming and damaging their outer surface (called the lipid membrane). There is a major open question however: what factors make brain cells sensitive to beta-amyloid? […]

Cacao (Theobroma cacao) cultivation in Latin American countries contribute 16% to the global production, employing around 2 millions of people, generating profits of around $100 million/yr to chocolate manufacturers. Cacao production is challenged by several fungal diseases that lead to decreased crop yield causing farmers to abandon the cacao business and cultivate other crops that […]

Non-invasive imaging of hemodynamics is known to enhance screening and monitoring of cardiovascular diseases (a leading cause of death in Canada’s aging population), however clinicians lack an imaging tool that can visualize the complex 3D and dynamic nature of hemodynamics in real-time. To meet such clinical needs, this project will aim to devise the first […]

Il a été démontré que les tumeurs exploitent certains mécanismes liés aux récepteurs immunitaires (point de contrôle) pour échapper à la réponse immunitaire. La mise sur le marché d’anticorps monoclonaux (mAbs) approuvés par la FDA, pembrolizumab et nivolumab en tant qu’inhibiteurs du récepteur immunitaire programmed death-1 (PD-1), et du durvalumab et de l’avelumab qui ciblent […]

The “CLiC” microscopy technique was invented and developed by Prof. Sabrina Leslie and her lab at McGill. It is ideal for formatting and visualizing single molecules, like DNA and proteins, with advantages that overcome the limitations of other single-molecule techniques. Due to the increasing interest in the technique from academic and industrial researchers, Prof. Leslie […]

NanoDendrix™ is a completely natural form of glycogen, sourced and produced from plants by a patented green process developed in Guelph, Ontario. Recent studies have revealed many valuable properties and performance characteristics of NanoDendrix, such as its antimicrobial effects, which have wide-ranging implications for clinical use. The proposed internship will evaluate NanoDendrix for use in […]