It remains unclear which factors drives variation in the gut microbiome across humans. Past work has taken an evolutionary perspective and compared the gut microbiome of humans on Western diets to wild primates and humans on non-Western diets and identified particular microbes which are at different abundances. However, the focus of these studies has mainly […]

The intention of this project is inquiry into the role of force signaling in skeletal muscle repair. Before muscle damage, muscle stems cells that are yet to be incorporated in the muscle fibers are relatively inactive, but when injury occurs they can multiply and are recruited to the site of damage. Many aspects of the […]

The heart beats 3-4 billion times in a person’s lifetime, making it the only part of the body that continues to work – without a break – for one’s entire existence! For this to occur, the heart must be highly regulated, so that is continues to function normally. Much of this regulation occurs within the […]

The focus of this project is to screen for small-molecules that may interact with the machinery that controls the decision of life and death in the cell. Diseases can arise from aberrant control of cell life and death like cancer and neurodegeneration. By shutting off the cell death pathway when cells are injured, or stressed […]

La tomographie d’émission par positrons (TEP) est une modalité d’imagerie médicale permettant le diagnostic et le suivi de cancers, maladies neurodégénératives et maladies cardiométaboliques. La prochaine percée majeure en imagerie TEP repose sur la mesure de temps-de-vol (TdV) ultra-rapide, nécessitant une excellente résolution temporelle des détecteurs du scanner. Les détecteurs conventionnels ne possèdent malheureusement pas […]

Airborne pathogens can easily and quickly spread respiratory diseases. Devices currently used for protection in hospitals, such as N95 respirators, rely only on filtration. Additionally, surgical masks have been increasingly used, although not effective against aerosols. This has been observed during past pandemics and epidemics of severe acute respiratory syndrome (SARS), swine flu, and Middle […]

Glutamate, the most widespread excitatory neuromediator in the brain, plays an important role in learning and memory functions. At very high cerebral concentrations it is likely to cause pathological effects (nerve cell death), such as those encountered in ischemic stroke. To reduce the toxic concentrations of glutamate in the brain, several approaches have been developed. […]

The goal of this project is to further develop the JGI technology CRAGE, which enables the insertion of large DNA fragments into the chromosome of a host organism. Over the course of the 3 months, the CRAGE system will be adapted for the E. coli EPI300 strain that is host to the Hallam Lab functional […]

My research has focused on optical nanoantenna-based plasmonics for achieving improved performance in optical applications. Recently, I have researched on energy transfer through nanoantenna waveguides and nanopixel color presenting with nanostructures. I have also systemized the optical setups including EOT/SPR biosensor, plasmonic lithography, and I have working on multichannel imaging system. During the visit, I […]

This project aims at evaluating whether recent results in deep learning models, trained to exploit weak labels (Hwang, 2016) can serve to extract meaningful lesion localizations from image-level labels, either from individual scans or given a (longitudinal) sequence thereof. To this end, we will scale up existing models that have been shown to work on […]

L’herpèsvirus humain 6B (HHV-6B), virus de la roséole, infecte près de 95% de la population avant l’âge de deux ans. Il est connu qu’HHV-6B intègre son matériel génétique aux télomères de la cellule qu’il infecte, régions des chromosomes qui contrôlent la durée de vie des cellules. Il est anticipé qu’une insertion d’HHV-6B à cet endroit […]

Craniofacial fractures require stabilization to restore appearance, facilitate healing and improve patient’s outcomes. The current standard of care is rigid titanium plates, which require drilling, screws and bending of titanium plates with plyers during surgery to conform to the complex geometry of the face. This is an over engineered solution that is not only difficult […]