The proposed project will investigate fish spermatogenesis in the seminiferous tubules of the testis. Specifically, it will look at the underlying endocrine and paracrine mechanisms that control the different phases of spermatogenesis, with focus on the spermatogonial phase, including the spermatogonial stem cells. This would include studying the in vitro effect of androgens on the […]

More than half of all women suffer from some form of pelvic floor disorder over their lifetime, with pelvic organ prolapse and urinary incontinence being the two most common presentations. High impact physical activity is one risk factor for the development of pelvic floor disorders, where it has been postulated that repeated impacts experienced chronically […]

This study aims to develop a scoring system to screen the sub-clinical forms of rotator cuff tears and predict the tear progression. All the medical, genetic, work, and lifestyle backgrounds of individuals with rotator cuff defects (with and without symptoms) will be evaluated and a battery of manual tests and measurements will be performed to […]

Cytochromes P450 are enzymes that add oxygen to organic molecules, to convert them to water-soluble products that can be further metabolized. These oxidative enzymes are ubiquitous (found in animals, plants and microorganisms). We are working on cytochrome P450cam, isolated from a wild soil bacterium. This enzyme catalyzes the oxidation of camphor (an organic molecule that […]

This proposed research builds on my current PhD thesis research, where I have characterized and validated a micro-tissue engineering platform that can be used to efficiently generate pancreatic islet-cell clusters (“pseudoislets”) that have significantly increased insulin secretion capacity, and superior capacity to reverse diabetes in animal studies. These findings have suggested a strong therapeutic prospect […]

Il y a peu de traitements efficaces pour réduire les symptômes de douleur associés à l’arthrose. Ceci est en partie dû à nos connaissances limitées sur le sujet. Plusieurs modèles ont été développés et celui qui se démarque est celui de l’injection intra-articulaire de mono-iodoacétate (MIA). Bien que le modèle de MIA chez le rat […]

Glucose monitoring has improved significantly over the last few years. Devices have become smaller, and today wireless wearable devices offer a seamless solution for people who require to monitor their glucose level multiple times daily. However, wearable devices are not always well accepted by people. Furthermore, monitoring solutions that are completely autonomous face acceptability issues […]

Cannabis sativa is a plant well-known for its production of cannabinoids, which are lipids with unique pharmacological properties. These compounds are produced mainly in female floral buds in specialized epidermal outgrowths known as glandular trichomes. These structures consist of a long stalk supporting a disk of biosynthetically active cells that produce the cannabinoids. Cannabinoid biosynthesis […]

The main goal of this research project is to understand how the consumption of fructose can lead to the developement of hypertension. Hypertension is one of the most world spread health condition and a major risk factor for cardiovascular diseases, stroke and death. The high presence of fructose in the body, whether directly due to […]

Hearing aids are a common form of treatment for individuals suffering from a hearing impairment [1]. These devices work by collecting sound from the surrounding environment and amplifying that sound in the patient’s ear to improve hearing [2]. These devices work well under most conditions however, in noisy settings such as a busy restaurant, hearing […]

Diphtheria is still a disease causing significant morbidity and mortality in people worldwide that did not received vaccination or suffer from incomplete immunization. The disease is due to a powerful toxin produced by the pathogenic bacterium Corynebacterium diphtheria. A good vaccine already exists but its production is rather complex and involves several steps: cultivation of […]

Immunovaccine Inc. is developing cancer vaccines using the company’s DepoVaxTM vaccine technology. DepoVax is a patented formulation that displays excellent tumor control and provides a long lasting and specific effect. The way by which this vaccine exerts its effect is unclear but the translational team at Immunovaccine is determined to discover its mechanism of action […]