The hormone insulin rises in the blood after consuming food. Too high of an insulin response may be a sign of dysfunctional metabolism and has also been shown to promote weight gain. Thus, if insulin levels rise too high after a meal it may indicate that someone is metabolically unhealthy or is prone to obesity. […]

Phytoene is a colorless carotenoid that absorbs light in UVA(286nm). It has powerful antioxidant and UV blocking effect and is used as a useful cosmetic material that can cope with the urban aging of skin in modern people. The purpose of this study is to construct and optimize phytoene biosynthetic pathway using E. coli. To […]

-Lemon Aspen is an indigenous plant of Uncandy and its extract contains terpenes (FPA and its derivatives) which have high efficacy such as skin whitening, pore contraction, anti-inflammatory, antioxidant, anti-inflammatory and antibacterial. -It is necessary to develop production technology based on biological process in order to solve the problem of delays in commercialization because it […]

Gut microbiome stability appears to be essential for keeping health nowadays. Then, the needs to develop proper tools to modulate microbiome become important issue. In this proposal, we suggest predatory bacteria as microbiome modulator. Predatory bacteria are ubiquitous in the environment and non-toxic to mammalian cells. Recent researches proved the existence of predatory bacteria inside […]

Dysfunctions of the placenta leads to a serious pregnancy associated disease of the mother called preeclampsia (PE) and certain forms of fetal growth restriction (FGR) that are hard to treat or prevent. Our laboratory has shown that overproduction of decorin, a molecule made by the pregnant uterus, leads to placental defects resulting in PE and […]

Sea cucumbers are found in both benthic areas and deep seas and have been used as a source of food and drug for decades. During the past decade, several scientific research initiatives explored various species of sea cucumber. However, not much research has been done on Atlantic species. As an emerging fishery in Atlantic Canada, […]

Ibuprofen is at the top of the World Health Organizations listing of essential medicines. As such, Ibuprofen is commonly consumed in nearly all countries. Considering Ibuprofen is poorly degraded by the human metabolism, wastewater tends to be a significant source of Ibuprofen in the environment. Concern has arisen over the past decade due to Ibuprofens […]

Genetic engineering has proven to be a useful approach for gene therapy and transformation of value-added agricultural plants. However, the current available technologies suffer from several limitations. These include relative low delivery efficiency with difficult-to-deliver cells or complex constructs and limit freedom-to-operate. Considering advances have been made in the applications of nanotechnology to life science […]

The proposed project will investigate fish spermatogenesis in the seminiferous tubules of the testis. Specifically, it will look at the underlying endocrine and paracrine mechanisms that control the different phases of spermatogenesis, with focus on the spermatogonial phase, including the spermatogonial stem cells. This would include studying the in vitro effect of androgens on the […]

More than half of all women suffer from some form of pelvic floor disorder over their lifetime, with pelvic organ prolapse and urinary incontinence being the two most common presentations. High impact physical activity is one risk factor for the development of pelvic floor disorders, where it has been postulated that repeated impacts experienced chronically […]

This study aims to develop a scoring system to screen the sub-clinical forms of rotator cuff tears and predict the tear progression. All the medical, genetic, work, and lifestyle backgrounds of individuals with rotator cuff defects (with and without symptoms) will be evaluated and a battery of manual tests and measurements will be performed to […]

Cytochromes P450 are enzymes that add oxygen to organic molecules, to convert them to water-soluble products that can be further metabolized. These oxidative enzymes are ubiquitous (found in animals, plants and microorganisms). We are working on cytochrome P450cam, isolated from a wild soil bacterium. This enzyme catalyzes the oxidation of camphor (an organic molecule that […]