Antigen tracking of the DepoVaxTM-R9F cancer vaccine using MRI

Immunovaccine Inc. is developing cancer vaccines using the companys DepoVaxTM vaccine technology. DepoVax is a patented formulation that displays excellent tumor control and provides a long lasting and specific effect. The way by which this vaccine exerts its effect is unclear but the translational team at Immunovaccine is determined to discover its mechanism of action and why their proprietary DepoVax technology delivers superior responses in comparison to other vaccines. This project will aim to figure out, using preclinical models, how the vaccines components are being transported within the immune system and which cells are responsible for this transport. The vaccine components will be labeled so that it can be tracked using magnetic resonance imaging (MRI) in the presence or absence of immune cells at the frontline of the immune system, like dendritic cells and macrophages. TO BE CONT’D

Faculty Supervisor:

Kimberly Brewer

Student:

Marie-Laurence Tremblay

Partner:

Immunovaccine Inc.

Discipline:

Visual arts

Sector:

Life sciences

University:

Program: