Myelofibrosis is a chronic and life-threatening blood disease. There is a need for accurate risk stratification approaches to guide personalized medicine decisions for these patients. To address this need, we developed a non-invasive blood-based test that is cost-effective, scalable and accurate. Through the Lab2Market program we will explore the market and develop the business case […]

We will assess the quality and suitability of blood and blood-derived products using a fast and economical approach that combines measurements of molecules in the blood product identified by their weight and computational approaches to make sense of all the data generated. Normal blood products have thousands of small molecules in common. By monitoring a […]

“RemoteCare” is a novel initiative that empowers individuals to conduct part of their medical assessments independently via a user-friendly remote digital solution. By enabling self-assessments, it reduces physician workload, minimizes wait times, and ensures quicker access to medical assistance, especially in underserved areas. However, its progress hinges on gaining the trust of traditional healthcare providers, […]

Medical devices and implants that cross the skin do not seal well with the skin, making them prone to infections and eventually failure and removal. We propose a bio-inspired coating for these devices. This coating will help these devices adhere to the skin and prevent bacteria from entering the body and causing infections. The coated […]

In Canada, heart failure (HF) has a 30-day re-admission rate of 17.6%. While patient care at home via follow-ups and self-management may reduce this rate, factors including physical fatigue and cognitive frailty delay follow-up visits and impair the patient’s ability to self-manage. An implantable solution such as CardioMEMS is available to monitor HF, however, its […]

Our proposed research project aims to answer the overall question: how do new arthritis medications taken during pregnancy affect mothers and their children? Many types of arthritis strike in females during their childbearing years. Even though we now know more about the effects of arthritis drugs when taken during pregnancy, the picture is not yet […]

Vaccination is an important preventive measure against influenza infection during both seasonal epidemics and pandemic outbreaks. This research aims to understand the effect of early vaccination during influenza outbreaks. The objectives are to measure the effectiveness of early vaccination in terms of reducing disease burden (e.g., infection, hospitalization). We apply an important methodology, namely mathematical […]

In this study, patients with idiopathic scoliosis followed at SickKids will undergo topographic analysis using the Momentum Health scanning application in addition to standard of care clinical evaluation and x-rays. The study period is 1 routine clinic visit followed by 3 months after. Patients will self-scan 1x/month at home for the following 3 months. The […]

L’hydroxyurée est un médicament utilisé pour prévenir les complications de l’anémie falciforme ainsi qu’en chimiothérapie d’appoint pour certaines leucémies. En pédiatrie, l’hydroxyurée doit toutefois être ajustée selon le poids de l’enfant, ses prises de sang et la toxicité perçue. Or, au Canada, seule la formulation de 500 milligrammes est disponible. Ainsi, nos hôpitaux et nos […]

Heart transplantation depends on being able to move a donor heart from the location of harvest to the hospital where it will be implanted, and having the heart work once it is implanted. The time between excision and implantation is called the ischemic time. The safe ischemic time is about 4 to 6 hrs; hearts […]

Our proposed research project aims to answer the overall question: what is the actual risk of infections or cardiovascular events for patients with inflammatory arthritis that take novel arthritis medication (biologics) and how does it compare between different classes of these drugs, in real-world settings? As well as asking if the safety and effectiveness of […]

The proposed research will investigate two brain imaging measures that hold potential as tools for the diagnosis and assessment of traumatic brain injury (TBI), including mild TBI (mTBI)/concussion. One type of image provides information about structural damage to the brain’s anatomical connections, and the other about the functional connectivity of networks of brain regions that […]