Enhancement of signal quality in Near Infra-Red (NIR) spontaneous Raman spectroscopy using coherent detection techniques for use in real-time cancer microsurgeries

Raman spectroscopy is a compound identification technique that can be used for real-time identification of cancerous tissues during surgery. The development and clinical translation of an intraoperative surgical-guidance instrument based on this technique is the main objective of ODS Medical, a Canadian startup. However, Raman signals are intrinsically very weak thereby requiring the measurements to […]

Read More
The Future of Mandatory Charging for Intimate Partner Violence: Status quo or alternative direction? Phases II and III

According to the Ontario Domestic Violence Advisory Council (DVAC, 2009), legislative responses to violence against women were introduced across Canada in the 1980s. These policies included provisions for mandatory police-laid charges against perpetrators of domestic violence. The DVAC report noted numerous unintended negative consequences of these policies and recommended an impact study which was never […]

Read More
Construction of Sustainable Corporate–Community Relations and Social Acceptance of Major Projects

The rise of local corporate–community conflicts surrounding development projects represents a trend rather than exceptional events, highlighting corporate–community relations as a prominent strategic issue. Despite the emergence of these issues for businesses, civil society, and governments, we still have a limited understanding of the conditions necessary for building and maintaining good relations over a long […]

Read More
Optimizing inter-device interaction in Drone-Aided Mobile Ad-Hoc Networks (DA-MANET) for Humanitarian Mission deployment

Every year, people suffer the consequences natural disasters descend upon them. When these unfortunate events occur, emergency response teams are deployed and need to deal with a multitude of challenges. In this scenario, the communication infrastructure is a key element that can contribute to the success of the mission. Considering the case of a Drone-Aided […]

Read More
Mevalonate Cascade Inhibition Sensitizes human Glioblastoma Cells to Temozolomide via Modulation of Autophagy

Glioblastoma multiforme (GBM), also known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive cancer that begins within the brain. There is no clear way to prevent the disease. Typically treatment involves surgery after which chemotherapy and radiation therapy is used. The medication Temozolomide (TMZ) is frequently used as part of […]

Read More
Immune modulation with checkpoint inhibitor antibodies targeting GITR or OX40 to improve cancer immune therapy with DepoVaxTM vaccine and metronomic cyclophosphamide

Immunovaccine Inc. is developing immune therapies for cancer using the company’s DepoVaxTM vaccine technology. DepoVax is a patented formulation provides controlled and prolonged exposure of antigens and adjuvants to the immune system, resulting in a strong, specific and sustained immune response. Immunovaccine’s translational research team is focused on improving responses in advanced cancers by combining […]

Read More
Enteroids and enteroid derived monolayer cultures: Using primary intestinal epithelial cell cultures to define the mechanisms underlying epithelial intrinsic innate defenses

Using growth media available from Stemcell technologies, along with our own tools and techniques, we can isolate and grow intestinal stem cells from mice or human patient donors into enteroid cultures. Enteroids are 3D cell cultures that replicate many of the structures and types of cells found in the intestinal lining. We propose to work […]

Read More
Technology to improve walking competency in seniors

Walking pattern in healthy adults changes with age. A poor walking pattern results in fall and fear of falls. It is important to detect early changes in gait so that corrective measures are taken. In this project I am planning to use a sensor (Heel2Toe device) that detects when an individual makes a correct step […]

Read More
Modeling of dynamic seat and backrest adjustments for manual wheelchairs

During an average day, a wheelchair user will be required to undertake a variety of different tasks. However, wheelchairs are usually designed in a fixed configuration and cannot adapt to different situations. Models such as PDG Mobility’s “Elevation” wheelchair address this issue by allowing users to adjust their position while still seated. We aim to […]

Read More
Implementation of an adventitious agent assay by HTS

Manufacturing of consistently high quality products is the commitment of the pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results must meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing […]

Read More
Développement de thérapies géniques pour l’Ataxie de Friedreich

Le but du projet de recherche est de développer une thérapie pour une maladie héréditaire sévère appelée l’Ataxie de Friedreich. Cette maladie est due à une mutation dans le gène de la frataxine qui réduit la production de cette protéine mitochondriale. Des expériences seront faites sur des souris modèles de cette maladie. Comme les patients, […]

Read More