Modern molecular targeted therapies have shown promise in treating some blood cancers, but a cure remains elusive for most acute leukemia patients. This is largely due to the survival of some leukemic cells that possess unique properties and can cause treatment failure or relapse, warranting identification of new, distinct targets for improved therapies. In collaboration […]

The specific aim of this project is to design and manufacture affordable, high fidelity, and high quality synthetic surgical training models of diseased valves and arteries to simulate the possible surgical options such as prolapse mitral valve reconstruction surgeries, aortic valve repair for aortic insufficiencies (novel idea) and coronary and radial arteries [side to side […]

Currently there is a huge challenge in drug screens as the vast majority of the candidate drugs fail in clinical trials either due to no efficacy or drug toxicity. As an alternative to traditional animal models, zebrafish have recently emerged as a powerful vertebrate paradigm to study human disease and to use its developing embryos […]

The scientific challenge for this research project is to advance our understanding of the impacts of heat stress in heat vulnerable workers and to use this information towards the creation of intelligent heat stress monitoring and management solutions to safeguard health and wellness. Currently, our understanding of the effects of heat exposure on vulnerable individuals […]

As a result of the baby boomer generation, an increasing proportion of Canada’s population is now comprised of older adults / senior citizens. Increased numbers of these older adults are living in private Retirement Homes, and these consumers are emphasizing resident safety programs/policies when deciding between facilities. Towards providing state-of-the-science care for their residents, the […]

National Legalization of Cannabis has occurred in Canada. Very little is known about the different compounds in the Cannabis Plant. The two main compounds are THC and CBD. Both of them have shown some benefits for different conditions. We would like to determine the best dose and ratio of compounds within the Cannabis plant for […]

There are many ways for scientists to study lung diseases.  One way that scientists try to understand lung disease is by growing and examining lung cells in the lab.  While most cells are grown submerged in special liquid that provides the cells with nutrients, a more sophisticated model is to grow cells in an air […]

Approximately 5% of the population has a Spondylolisthesis (one of the lower vertebrae slips forward onto the bone directly beneath it). Non-invasive image-based assessment of this spinal structure is an increasing demand in healthcare service. However, the massive information embedded in the increasing large imaging scans has made manual inspection a lengthy and tedious task […]

Muscle wasting is a common complication of many diseases such as cancer, chronic heart and lung disease and results in weakness, impaired quality of life and shortened survival. There are no drugs for the treatment of muscle wasting. We have identified a gene, USP19, in the ubiquitin pathway which is the major pathway of protein […]

CHLNet identified the need for valid, reliable tools to determine the impact of these health leadership development programs. This project will develop a practical, easy to use toolkit to facilitate the measurement of program outcomes and impacts. The toolkit will be pilot tested and evaluated across the country according to defined selection criteria. The finalized […]

The interns will develop novel technologies using laser light to interrogate molecular vibrations in biological tissue setting up the stage for the next generation of intraoperative imaging techniques used to guide surgical interventions, including the resection of tumours in prostate and ovarian surgery as well as in neurosurgery. The partner organisation (Optech) is an organisation […]

Parkinson’s Disease is the second most common neurological disorder. Over the course of the disease the brain cells that produce dopamine are slowly dying. The loss of these dopamine-producing cells means that less dopamine is available in the brain, causing many symptoms such as tremors. Unfortunately, brain cells cannot regenerate, so a patient’s symptoms will […]