Raman spectroscopy is a compound identification technique that can be used for real-time identification of cancerous tissues during surgery. The development and clinical translation of an intraoperative surgical-guidance instrument based on this technique is the main objective of ODS Medical, a Canadian startup. However, Raman signals are intrinsically very weak thereby requiring the measurements to […]

Human Crif1 is a protein with multiple functions, playing important roles in embryonic development, cellular stress, cell cycle regulation and mitochondrial membrane integrity. CRIF1 is coined to play a regulatory role in the Bone Marrow microenvironment-induced leukemia cell cycle arrest possibly through interacting with CDK2 and acting as a cyclin-dependent kinase inhibitor. In this project, […]

Arthritis affects 4.6 million Canadians and the demand for timely and effective care is critical to better patient outcomes and cost effectiveness. The research projects will identify better models of care delivery for: 1) at risk patients with obesity who may require knee and/or hip replacement surgery or require conservative medical treatment in place of […]

Low back pain is a leading cause of disability worldwide. The Canadian Armed Forces (CF) has a greater incidence of LBP than the general population. LBP is responsible for a large proportion of medical releases in the CF with many cases resulting in lifelong pain and disability. Improved early access to evidence-based care could help […]

The proposed research will allow us to determine how the human central nervous system (i.e. brain and spinal cord) functions to produce different intensities of muscle contractions with and without fatigue. We will use a variety of stimulation technics to determine how active the brain and spinal cord are during the arm contractions. We do […]

Riverview Health Centre (RHC) plans to renovate their special care units and grounds, which accommodate 60 residents with intermediate and advanced stages of dementia. The main purpose of this study is to examine the effects of the renovations on residents, family and staff using a multi-methods research approach and a multi-disciplinary team of researchers (i.e., […]

We aim to develop tools to assess patient outcomes following treatment and removal of bone metastases. We will identify markers for enhanced patient outcomes, so as to predict which patients may benefit from more aggressive treatments to better their quality of life. We also aim to use 3D printed bone implants to help in the […]

This project aims to assess how the use of the novel “ultra-short echo-time” (UTE) MR imaging technology can “add value to” conventional MRI for detection and quantification of blood products in hemophilic joints. We will test this novel technology in joints of hemophilic patients with different stages of arthropathy presenting with blood products at different […]

Seizures are rare while dreaming in rapid eye movement (REM) sleep. New research, however, suggests seizures may rebound during unstable REM sleep. This may be due to brain wiring (“connectivity”) since a highly connected brain is more prone to seizures, and connectivity changes from wakefulness to sleep. Brainwave tracings (“EEG”) can generate connectivity maps (“connectomes”) […]

Community hospitals in small towns or rural areas face challenges in delivering health care that will allow elderly members of their community to remain in the community that they helped to build. Using simulation modelling, this project will develop strategies for delivering complex continuing care in rural hospitals that is closely integrated with long-term care, […]

We propose a novel approach that will provide researchers with an improved method to study multiple molecules, simultaneously in the same tissue section. Our strategy is to use novel nanoparticles that each emit unique multispectral signature and can be used simultaneously. We aim to develop a novel method to detect 15 breast cancer and immunotherapy-related […]