Intracellular growth of Mycobacterium tuberculosis: prospects for drug discovery

The success of Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), lies in its ability to primarily infect, reside, and multiply in the lungs of patients. Mtb infects white blood cells termed alveolar macrophages and hides from the host immune response as well as from many antibiotics used for treatment, creating additional challenges for […]

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Wintering Hills Reverse Auction

This research would determine the costs of securing and restoring drained wetland areas on private lands in the Wintering Hills area of Alberta, Canada, through the use of an approach called a “reverse auction.” Collaborating with Ducks Unlimited Canada, the project would pay farmers to allow wetlands to be restored on their property. The payment […]

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Physiological and environmental factors affecting the migratory behavior and survival of sockeye and steelhead salmon smolts

The great number and variety of factors influencing the survival of migrating salmon smolts in the early marine environment makes it difficult to understand the causes of recent declines in smolt survival and salmon population productivity. We will combine novel methodologies (biotelemetry and biomarkers) simultaneously to examine a variety of factors influencing the migratory behaviour […]

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The health impacts of residential eviction among people who use drugs in Vancouver, Canada

Over the past decade, there has been a steady rise in homelessness in Canadian cities due in large part to loss of low-income housing stock in inner-city neighbourhoods undergoing redevelopment. People who use drugs (PWUD) disproportionately face eviction from buildings targeted for renovation and demolition and also face significant barriers in subsequently obtaining affordable housing. […]

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Assessing electronic medical record technology in a multi-site setting in an urban slum in Nairobi, Kenya

Health information systems (HIS) such as electronic medical records systems (EMRS) have shown promise in facilitating improved health care delivery in both developed and developing nations. Kenya, has actively invested in HIS to manage the increasing burden of both communicable and non-communicable diseases. This is particularly relevant because since 2008, due to rapid urbanization, and […]

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Getting to Groundbreaking (G2G) Year 3 Focus on Hi-Rise

The Gettmg to Groundbreaking project 2015-16 seeks to engage two masters student interns for Sept 2015- June 2016 in order to complete original research tnto the home building poficy and process applicable to high-rise developments in municipalities in the Metro Vancouver region and Abbotsford The interns will conduct survey, interview, secondary and case studyba. sed […]

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Use of remote sensing data to define spatial-temporal salmon habitat status

The Salish Sea is a temporally and spatially dynamic coastal ocean under strong influence from terrestrial and oceanic inputs, and of major economic importance, due in part to fisheries. The Salish Sea is highly productive, especially from early spring to summer when resident and migratory fish populations are either spawning or entering. The interannual productivity […]

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Enviromètre

L’objectif principal du projet Enviromètre est de produire une enquête annuelle comportant une batterie d’indicateurs d’opinion publique. Ces indicateurs permettront de faire le suivi de l’évolution des croyances, priorités et préférences des Québécois et Canadiens en ce qui a trait aux enjeux environnementaux. En plus de cette enquête principale, le projet produira d’autres études de […]

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Targeting CD73 for the immunotherapy of glioblastoma

With an average median survival of 14 months, glioblastoma multiforme (GBM), the most common and most aggressive primary brain tumor occurring in adults, represents an unmet medical need and new therapeutic options with a significant impact on patients survival are eagerly awaited. Our laboratory recently identified the enzyme CD73 as a new target for cancer […]

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Targeting CD73 for the immunotherapy of glioblastoma – Year 2

With an average median survival of 14 months, glioblastoma multiforme (GBM), the most common and most aggressive primary brain tumor occurring in adults, represents an unmet medical need and new therapeutic options with a significant impact on patients survival are eagerly awaited. Our laboratory recently identified the enzyme CD73 as a new target for cancer […]

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Identifying the molecular mechanisms of neutrophil extracellular trap (NET) formation and screening NETosis-suppressing drugs to treat cystic fibrosis lung disease

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) […]

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