Identifying the molecular mechanisms of neutrophil extracellular trap (NET) formation and screening NETosis-suppressing drugs to treat cystic fibrosis lung disease – Year Two

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) […]

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Training, engagement, and retention: a ‘learning region’ approach to rural youth

Youth are tomorrow’s leaders, parents, professionals, and workers, as well as today’s assets. However, the disengagement and out-migration of rural youth are critical challenges for rural communities and regions. In the Lower Columbia and surrounding West Kootenay-Boundary region these challenges are compounded by struggles to meet existing labour force needs. This project will review, summarize, […]

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The effect of an innovative parent training program to promote parental reflective function and child development in high-risk families

Parents suffering from toxic stress (depression, addictions, and/or family violence) are often unable to respond sensitively and appropriately to their infants, putting the health and development of their infants at risk. My research evaluates a new parenting program called ATTACH. In ATTACH, parents learn to reflect on how they parent and to better understand their […]

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Diversity and structure of coastal eelgrass communities and their importance for maintaining juvenile Pacific salmon

On the coast of British Columbia, both eelgrass meadows and Pacific salmon species are declining, yet eelgrass community dynamics and reliance of juvenile salmon on these communities are poorly understood. We will assemble the first large-scale dataset from monitoring efforts of coastal BC organizations in order to assess eelgrass community diversity and structure across environmental […]

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Diversity of coastal eelgrass communities and their importance for maintaining juvenile Pacific salmon – Year Two

On the coast of British Columbia, both eelgrass meadows and Pacific salmon species are declining, yet eelgrass community dynamics and reliance of juvenile salmon on these communities are poorly understood. We will assemble the first large-scale dataset from monitoring efforts of coastal BC organizations in order to assess eelgrass community diversity and structure across environmental […]

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Developing an Indigenous-led ‘conservation economy’: Ecosystem service synergies and trade-offs from shellfish aquaculture in British Columbia’s Great Bear Sea

Without careful management, the growing number and intensity of human activities can negatively affect ecosystem health and cause conflict between users. Recognizing the need for integrated management, the Province of British Columbia and 18 Coastal First Nations collaborated to develop an integrated spatial Marine Plan for the North Pacific Coast. A critical part of implementing […]

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Identification of STAT3/5 Advanced Preclinical Candidates

It is estimated that 1 in 2/3 people will be diagnosed with cancer in their lifetime. Cancer is a genetic disease characterized by the uncontrolled growth of cells. While treatments are available for many cancers, remission of the disease, side-effects of the medication, and the onset of resistance by the cancer to the drugs being […]

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DeepCity

DeepCity is a strategy game initially for iOS, Android and desktop that is set in a strange, fascinating near future of mega-storms and scarcity. The goal: Survive. Defend. Regenerate. DeepCity advances concepts of resilience, urban ecology, sustainable futures, and systems-thinking within urban environments for players. The DeepCity prototype research project will provide the student with […]

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Élaboration d’un poisson virtuel pour évaluer le comportement ichtyophile d’une turbine hydraulique

Un outil de « poisson virtuel » est développé pour évaluer les dommages potentiels aux poissons traversant des turbines hydrauliques de barrage. Il se base sur le traitement de résultats de simulations numériques de ces turbines afin d’estimer la trajectoire probable du poisson et ainsi déterminer si les conditions de pression qu’il rencontre lors de […]

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Optimisation du procédé d’assemblage des connecteurs métalliques en cuivre

La maintenance et l’entretien des hydro-génératrices nécessitent parfois la réparation des conducteurs de cuivre des alternateurs. La méthode de réparation par brasage à la torche, actuellement utilisée, comporte plusieurs inconvénients techniques rendant la réparation sur site difficile à mettre en oeuvre. La réparation des alternateurs génère des arrêts importants et peu prévisibles de la production […]

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