A Data-Driven Automation Framework for Chromatography-based Purification of High-value Biotherapeutics

A critical task towards maximizing productivity in the manufacturing of biotherapeutics such as monoclonal antibodies is selecting the appropriate separation technology or sequence of technologies that meet the purity requirements of regulatory agencies (e.g. Health Canada) and maximize product recovery to reduce the overall cost per dose. The focus of this research project is two-fold. First to develop new performance monitoring tools for continuous chromatography processes. Second to optimize the downstream purification process by removing process bottlenecks and incorporating process simplifications. Sartorius, the partner for this project, will provide the state-of-the-art equipment that is needed to conduct the experimental work and student training opportunities at their R&D facilities in North America and Europe. As a global leader in biopharmaceutical manufacturing and life sciences research, Sartorius is ideally suited to translate the outcomes from this research project into the biotherapeutics manufacturing facilities of their wide network of clients.

Faculty Supervisor:

Prashant Mhaskar;David Latulippe


Ian Gough




Engineering - chemical / biological



McMaster University



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