Antibacterial activity of silicone porphyrins

Porphyrins and phthalocyanines are important biological molecules that, for example, control respiration of plants (chlorophyll helps convert C02 to oxygen) and heme controls the 02/C02 balance in human blood. Such compounds possess many other regulatory roles. In the presence of light some of these compounds convert oxygen into ‘reactive oxygen species’ (ROS). ROS aggressively attack biological molecules. In some cases, the ROS can destroy pathogens, including fungi and bacteria. Silicones are widely used in applications ranging from bathtub sealants to contact lenses; they are very resistant to oxidation. In this project, we will combine porphyrins and silicones with the objective to create antibacterial rubber interfaces. Porphyrins will be tethered to silicone elastomers at or near the air interface. Bacteria (models – E. coli) will be exposed to the surface and the ability to kill the microorganisms in light and dark will be optimized.

Faculty Supervisor:

Michael Brook

Student:

Partner:

Suncor Energy Inc (Mississauga, ON)

Discipline:

Physics

Sector:

Agriculture; Manufacturing; Mining

University:

McMaster University

Program: