Aortic arch haemodynamics in adult women with Turner syndrome: A numerical investigation into obesity-related factors

Girls with Turner syndrome (TS), a chromosomal condition in which a female has complete or partial absence of the second sex chromosome, present a unique group of patients, with an increased risk of cardiovascular disease. Since the mid 1900s extensive research has led to advancements in the treatment of Turner syndrome: growth hormone therapy can increase final adult height, and reproductive treatment can assist with infertility. However, cardiovascular diseases affecting girls and women with TS remain under-researched, and remains the leading cause of death. Our research aims to contribute to one of the key cardiovascular research priorities outlined in a scientific statement from the American Heart Association, which is to increase our understanding of the haemodynamic environment and, ultimately, flow-related cardiovascular disease markers in patients with Turner syndrome. We will do so by reconstructing 3D models of the aorta and performing blood flow simulations using computational fluid dynamic methods.

Faculty Supervisor:

Cristina Amon

Student:

Partner:

University of Strathclyde

Discipline:

Engineering

Sector:

Health and Related Sciences & Technology; Biotechnology; Technology

University:

University of Toronto

Program: