Assessment of Salmonella enterica and Campylobacter jejuni inhibition using lead single domain antibodies in combination with dysregulators of the master protease ClpP

The human pathogenic bacteria Salmonella enterica and Campylobacter jejuni are commonly found in the intestine of poultry. Consumption of infected chicken and eggs, and its derivatives, is the main and most important source of infection outbreaks in humans causing diarrhoea, fevers and abdominal cramps. In some cases, severe diarrhea and dehydration followed by systemic spreading of these infections is life-threatening. At present, no widely effective strategy is available to control both Salmonella and Campylobacter colonization of broiler chickens to prevent the infection in humans. To this end, AbCelex has developed a novel strategy of using single domain antibodies (sdAbs) to control the level of Salmonella and Campylobacter in poultry meat by administering them as feed additives. sdAbs are the smallest antibodies known in nature and are produced by members of the family Camelidae (like camels, llamas and alpacas) and sharks. TO BE CONT’D

Faculty Supervisor:

Walid Houry

Student:

Philbert Ip

Partner:

AbCelex Technologies Inc

Discipline:

Biochemistry / Molecular biology

Sector:

Agriculture

University:

Program: