Autotaxin inhibition as a novel treatment to improve outcomes from chemotherapy and radiotherapy for cancer patients

We will investigate a new approach to improving the treatment of cancer patients. Chemotherapy and radiotherapy lose effectiveness and produce side-effects that are deleterious. For example, the development of scar tissue restricts the use of radiotherapy for several types of cancer. We will study a new type of drug, which will be supplied by our partner, that should decrease the formation of scar tissue after radiotherapy and also improve the effectiveness of radiotherapy and chemotherapy. The information gain should accelerate the introduction of this new approach and improve the outcomes of cancer patients.

Faculty Supervisor:

Frank Wuest


Zelei Yang


Brindley Associates Incorporated


Biochemistry / Molecular biology


Professional, scientific and technical services


University of Alberta



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