Discover more projects across a range of sectors and discipline — from AI to cleantech to social innovation.
Fibroproliferative disorders are a/the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the pathogenesis of IPF is incompletely understood, work from our group and others suggest that transforming growth factor beta 1 (TGF-?1) is involved in the fibrogenic process. PBI-4050 is a promising novel anti-fibrotic drug developed by ProMetic Life Sciences that is currently in phase II clinical trial in IPF. In this project, we will examine the anti-fibrotic effect of PBI-4050 in a TGF-?1 mediated animal model of lung fibrosis. This work will increase our understanding of the cellular and molecular mechanisms involved in pulmonary fibrosis and potentially lead to the development of new therapeutic strategies for IPF.
Find the perfect opportunity to put your academic skills and knowledge into practice!Find Projects
The strong support from governments across Canada, international partners, universities, colleges, companies, and community organizations has enabled Mitacs to focus on the core idea that talent and partnerships power innovation — and innovation creates a better future.