Characterizing the role of probiotics in physiologically relevant ex vivo and in vivo models of infectious colitis

In the intestines of people living with inflammatory bowel diseases (IBDs), the balance of beneficial bacteria is shifted. Instead, the intestine is overloaded with potentially harmful bacteria – a phenomenon known as dysbiosis. This shift in bacterial populations is believed to be among the key contributors to the onset of inflammation observed in IBD patients.
Bioactive bacteria that help to re-establish equilibrium in the intestine are known as probiotics. They work by promoting the growth of beneficial bacteria while simultaneously warding off harmful bacteria. Importantly, probiotics may alleviate intestinal injury and inflammation and thereby reduce some symptoms of IBD. However, less is known about the precise ways in which probiotics act on cells lining the intestine, and how this might contribute to improved IBD outcomes. Answering these questions is the underlying goal of the proposed research. TO BE CONT’D

Faculty Supervisor:

Philip Sherman


Shaiya Robinson


Lallemand Health Solutions


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