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Stroke is one of the most prevalent neurological conditions worldwide, especially among the elderly.
Motor impairment is one of the main disabilities associated with stroke. The ability of training and
physical activity to restore motor function after neural injury has long been appreciated. Nevertheless,
even with intensive task-specific training and physical activity, 15–30% of patients with stroke are
permanently disabled. As a result,research aiming to develop novel therapies that enhance
neuroplasticity is currently being conducted to allow rehabilitation of these patients. A promising
approach is modulation of cortical excitability using non-invasive brain stimulation techniques. These
techniques may instantaneously induce plastic changes within the cortical network of sensorimotor
areas, thereby improving motor function of the affected hand after stroke. Our work attempts to
elucidate whether repetitive administration of inhibitory non-invasive brain stimulation of the
unaffected hemisphere in sub-acute stroke over several days combined with sensorimotor
behavioural training using optical left-right reversing prisms could result in an enhanced effectiveness.
The primary objective is………….TBC
Richard Staines
Sunnybrook Health Sciences Centre
Life Sciences
University of Waterloo
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