Comparative effectiveness of prophylactic therapies for necrotizing enterocolitis in preterm infants: a network meta-analysis of randomized trials – Phase II

Necrotizing enterocolitis (NEC) is the most common and serious intestinal disease among premature infants. It happens when tissue in the small or large intestine is injured or begins to die off. This causes the intestine to become inflamed or, in rare cases, develop perforation. It is associated with significant mortality and morbidity in preterm neonates. Current literature on prevention of NEC lacks direct and indirect comparisons of available therapies. Using state-of-art methods (e.g. network meta-analysis) I intend to compare relevant preventive therapies and find out if there is any difference among them considering patient important outcomes. The partner has relevant expertise in a number of our interventions of interest, including formula milk with arginine, glutamine, prebiotics and probiotics. To BE CONT’D

Faculty Supervisor:

Bradley Johnston


Behnam Sadeghirad


Nestle Canada Inc


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