Course of immune responses generated by live Salmonella vaccine in pigs

Salmonella is the second most frequent cause of foodborne illness in Canada and pork is one of sources for human salmonellosis. Salmonella has also the potential to cause clinical disease in pigs. Salmonella is commonly found on Ontario swine farms. Thus control strategies should be implemented. Vaccination appears to be one of the most promising approaches. In Canada, there is currently available a live Salmonella Choleraesuis vaccine for use in pigs and a live Salmonella Typhimurium vaccine for use in poultry. However, the course of immune responses induced by the above vaccines in 11 pigs is not well studied. The objective of this proposal is to evaluate and compare the immune responses produced by these two Salmonella vaccines in pigs. This research can provide a better understanding of pig immune responses against Salmonella attenuated vaccines and will help to develop new vaccines for controlling Salmonella on Ontario swine farms.

Faculty Supervisor:

Dr. Robert Friendship

Student:

Abdolvahab Farzan

Partner:

Boehringer Ingelheim

Discipline:

Medicine

Sector:

Life sciences

University:

University of Guelph