Creation of candidate glucocerebrosidase PET imaging agents

Mutations in the enzyme glucocerebrosidase (GBA1) are the most common genetic risk factor for development of Parkinsons disease (PD). PD is characterized by the buildup of abnormal protein deposits in the brain, followed by progressive loss of neurons and behavioural symptoms. Numerous studies have noted a correlation between reduced GBA1 activity and increased levels of these abnormal protein deposits in the brain, but the relationship remains poorly understood. The aim of this project is to create an inhibitor that can enter the brain and be used to determine GBA1 in the brain. The success of this project may lead to a better diagnostic agent for PD.

Faculty Supervisor:

Andrew Bennet

Student:

Sachin Kandalkar

Partner:

Alectos Therapeutics Inc.

Discipline:

Chemistry

Sector:

Medical devices

University:

Program: