Development and validation of highly specific antibodies against O-GlcNAcylated epigenetic regulators

For the last decades, tremendous efforts have been made to establish the principles that govern the physiopathology of living organisms. We learned that post-translational modifications (e.g., phosphorylation and ubiquitination) play major roles in the regulation of cellular processes. But we still have much to gain in this vast field. Importantly, deregulations in cell signaling pathways underlie numerous human diseases, emphasizing the critical need for establishing novel tools and approaches that can be used in basic, translational or clinical research settings. Our team revealed a gap regarding the available molecular tools used for identifying specific and important post-translational modification. Thus, there is an urgent need for developing novel highly specific probes to detect these post-translational modifications, and this will be the objective of my investigation. Médimabs will gain an expertise in this field as a technology transfer would take place. Moreover, these reagents will enrich the company products portfolio.

Faculty Supervisor:

El Bachir Affar

Student:

Salima Daou

Partner:

Discipline:

Biochemistry / Molecular biology

Sector:

Medical devices

University:

Program:

Elevate