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Development of a biosensor for high-throughput screening of novel ezrin inhibitors for treatment of metastatic breast cancer.
Treatment of metastatic breast cancer is often unsuccessful and lead to 5000 deaths in Canada each year. Therefore, there is an unmet need for new drugs for prevention and/or treatment of metastatic disease. Ezrin is a protein marker commonly over-expressed in metastatic breast cancer. Preclinical studies show that blocking ezrin can significantly reduce metastasis in breast cancer models. In this proposal, the intern will develop novel biosensors to screen large numbers of compounds with the ability to block ezrin’s activity in cancer cells. The results of this project can be used to identify novel therapeutics to minimize metastasis in breast cancer. Additionally, the path to developing of new drugs can be expedited to clinical trials through our industry partner, Tika Therapeutics.
Faculty Supervisor:
Peter Greer
Student:
Partner:
Tika Therapeutics Inc
Discipline:
Life Sciences
Sector:
Manufacturing
University:
Queen's University
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.