Evaluation of Signal Mass as a new marker of brain tissue loss in multiple sclerosis

The degree of brain cell injury and death may be associated with disability and problems with memory and thinking skills in patients with multiple sclerosis (MS). This is most frequently measured by using magnetic resonance imaging (MRI) images to calculate shrinkage of brain volume. In fact, MS patients suffer more rapid shrinkage of brain volume compared to healthy people. However, brain volume can also fluctuate due to reasons other than brain cell death, such as water coming in and out of the brain. Also, brain volume change alone does not necessarily inform us regarding the change in the number of brain cells within the tissue (i.e. change in the density of brain cells). This project aims to evaluate Signal Mass (SM), a new method that combines both the volume shrinkage and cellular density information. TO BE CONT’D

Faculty Supervisor:

Sridar Narayanan


Hyunwoo Lee


NeuroRx Research Inc.




Medical devices




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