Exploring distinctions in microbial spatial distribution in patients with active and quiescent Crohn’s disease

Inflammatory bowel disease (IBD) is a chronic condition affecting the gastrointestinal (GI) tract, characterised by periods of remission and flare-ups. The two main types of IBD are Crohn’s disease (CD), which can affect any part of the GI tract, and ulcerative colitis, which affects the colon. Predicting flare-ups and choosing the best treatments are major challenges in managing IBD. The gut microbiota, the community of microbes in our GI tract, may serve as a useful marker of treatment success and disease flare.
While most research has focused on stool samples, microbes associated with with gut’s mucus and tissues might have greater impact on immune responses. This project aims to explore the difference in bacteria and fungi at various locations within and along the GI tract of patients with CD. By partnering with the IBD Centre of BC, we hope to improve personalised care and treatment options for IBD patients.

Faculty Supervisor:

Genelle Lunken

Student:

Partner:

The IBD Centre of British Columbia Society

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

The University of British Columbia

Program: