Identifying the molecular mechanisms of neutrophil extracellular trap (NET) formation and screening NETosis-suppressing drugs to treat cystic fibrosis lung disease

Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) in CF neutrophils. Furthermore to translate the findings for therapeutic targets, screening of large scale drugs, kinases and specific pathways inhibitors associated with NETosis are required. When therapies are developed and tested, It provides opportunities to train our healthcare professionals in the use of these drugs and therapies, assists in their dissemination and generates economic benefits. I have confident that our research findings would develop commercially applicable products, give back the economical benefits and commercial ventures to the organization (Cystic Fibrosis Canada). Over all findings would be definitely uplifting the socio-economical status of the organization.

Faculty Supervisor:

Nades Palaniyar

Student:

Meraj Khan

Partner:

Cystic Fibrosis Canada

Discipline:

Medicine

Sector:

Pharmaceuticals

University:

University of Toronto