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There currently are no approved treatments for COVID-19, as global case counts increase daily. High infectivity and long time-to-recovery for COVID-19 cases is straining health-care systems globally. There is an urgent need to discover therapeutics that treat patients and improve clinical outcomes. Research and Development timelines associated with vaccines and new chemical entities will not reach clinics in time to mitigate the current patient surge, leaving drug repurposing as the most practical short-term solution. Most repurposing efforts to date focus on drugs that have previously shown antagonistic activity against other viruses. A broad patient population with diverse pre-existing conditions calls for as many diverse treatment strategies as possible. This proposed project will apply AI technologies to mine the biological networks formed between virus and human proteins and predict existing FDA-approved drugs that can interrupt these interactions.
Bo Wang
Hamed Janani
Cyclica
Medicine
Professional, scientific and technical services
University of Toronto
Accelerate
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