Intra-arterial therapeutic dissolution of plaques in coronary and peripheral arterial diseases

Atherosclerosis is a disease characterized by chronic inflammation and LDL deposition in the lumen of the arteries. This process can result in stenosis or thrombosis. More than 33% of Canadian deaths in 2011 were due to cardiovascular events (major chronic diseases surveillance online). Canadians lose an average of 4.5 years of life expectancy due to CVD. In this respect, we strongly believe that development of the stent with a design to local and sustained release of statin and also, in the future, for proliferation of stem cells, can avoid the open heart surgery, which nowadays has elevate costs with the hospital and involves a high risk of a secondary infections during the rehabilitation of the patient. In this project we will develop a polymeric and biodegradable stent for sustained release of statins and also, in the future, for proliferation of stem cells.

Faculty Supervisor:

L'Hocine Yahia

Student:

Naziha Chirani

Partner:

Sarko Holdings Inc.

Discipline:

Engineering - mechanical

Sector:

Medical devices

University:

Polytechnique Montréal