Long-term effects of the administration of botulinum toxin BoNT-A, in a pre-clinical model of Parkinson’s disease

In the present project, we aim to contribute to the investigation of the potential use of botulinum toxin (BoNT-A) injections in the brain for the treatment of PD symptoms in the long-term. Particularly, we pretend provide evidence that allow optimize the use of BoNT-A, defining optimal concentrations and periodicity of treatment, as well as the description of the mechanisms involved.
The results obtained from this study are of great interest for MERZ, because this will permit continue with the evaluation of Botulinum toxin as a treatment for motor symptoms of PD, expanding the scope of application of this product that is already established in the in the industry, with delivery technologies available to humans.

Faculty Supervisor:

Mandar Jog


Alejandra Veronica Parra Pena


Merz Pharma Canada Ltd





University of Western Ontario


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