Mass spectrometry-based identification of post-translational modifications important for binding of bromodomain proteins

The objective of my research in the Fillingham Lab at Ryerson University is to understand how genes works since it is a fundamental process and its failure is implicated in many diseases. Understanding how genes works has shown to have promising outcomes in the treatment of many diseases since this research can reveal novel drug targets and scientists can produce molecules that can help with control over the genes causing disease to stop it. This project builds knowledge about gene function in a model system known for its abundant genetic material. The research is important for the pharmaceutical industry since the development of new drugs is of significant current interest to fight a variety of disease and infections. Finally, the proposed research benefits society by funding my training in the Taverna lab in Johns Hopkins University and in the Tackett lab in the University of Arkansas for Medical Sciences to develop a skill currently under-represented in Canada. The Taverna and Tackett lab are internationally recognized experts in this research field. The Taverna, Tackett and Fillingham labs will continue to collaborate on elucidation how genes work.

Faculty Supervisor:

Jeffrey Fillingham

Student:

Partner:

Johns Hopkins University;University of Arkansas for Medical Sciences

Discipline:

Life Sciences

Sector:

Life Sciences (not health); Health and Related Sciences & Technology; Pharmaceuticals

University:

Toronto Metropolitan University

Program: